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Kim, Jeong Beom
Molecular Biomedicine Lab
Research Interests
  • Patient-specific stem cells, induced pluripotent stem (iPS) cells, direct conversion, 3D bio-printing, Regenerative medicine, Patient-specific drug screening

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Direct reprogramming of human neural stem cells by OCT4

Cited 318 times inthomson ciCited 333 times inthomson ci
Title
Direct reprogramming of human neural stem cells by OCT4
Author
Kim, Jeong BeomGreber, BorisArauzo-Bravo, Marcos J.Meyer, JohannPark, Kook InZaehres, HolmSchoeler, Hans R.
Issue Date
2009-10
Publisher
NATURE PUBLISHING GROUP
Citation
NATURE, v.461, no.7264, pp.649 - 653
Abstract
Induced pluripotent stem (iPS) cells have been generated from mouse and human somatic cells by ectopic expression of four transcription factors (OCT4 (also called POU5F1), SOX2, c-Myc and KLF4). We previously reported that Oct4 alone is sufficient to reprogram directly adult mouse neural stem cells to iPS cells. Here we report the generation of one-factor human iPS cells from human fetal neural stem cells (one-factor (1F) human NiPS cells) by ectopic expression of OCT4 alone. One-factor human NiPS cells resemble human embryonic stem cells in global gene expression profiles, epigenetic status, as well as pluripotency in vitro and in vivo. These findings demonstrate that the transcription factor OCT4 is sufficient to reprogram human neural stem cells to pluripotency. One-factor iPS cell generation will advance the field further towards understanding reprogramming and generating patient-specific pluripotent stem cells.
URI
https://scholarworks.unist.ac.kr/handle/201301/7087
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=70349687407
DOI
10.1038/nature08436
ISSN
0028-0836
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BME_Journal Papers
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