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Do, Yoonkyung
DC-based Immune System & Immunotherapy (DISNI) Lab
Research Interests
  • Study on various subsets of dendritic cells and their immunological functions
  • Vaccine development by targeting pathogenic antigens to distinct DC subsets via anti-DC-subset-specific-receptor monoclonal antibodies
  • Characterization of roles of DCs in tumor microenvironment and tumor metastasis
  • Studies on role of DCs in neuro-related diseases
  • Study DCs in collaboration with Biotechnology or Engineering field

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Bryostatin-1 in combination with calcium ionophore promotes the maturation of human umbilical cord-blood monocyte-derived dendritic cells capable of activating neonatal alloreactive T cells

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Title
Bryostatin-1 in combination with calcium ionophore promotes the maturation of human umbilical cord-blood monocyte-derived dendritic cells capable of activating neonatal alloreactive T cells
Author
Do, YoonkyungMainali, ENagarkatti, PSNagarkatti, M
Keywords
Alloreactive T cells; Byrostatin-1; Calcium ionophore; Class II major histocompatability complex; Co-stimulatory molecule; Cord blood; Dendritic cells; Interferon-γ; Maturation; Tumor necrosis factor-α
Issue Date
2004-09
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Citation
CELLULAR IMMUNOLOGY, v.231, no.1-2, pp.8 - 13
Abstract
We have investigated the effect of bryostatin-1 (Bryo-1) and calcium ionophore (CI) on maturation and functions of DCs generated from adherent cells of cord blood cultured with GM-CSF plus IL-4 (CB-DCs). The CB-DCs treated with Bryo-1 + CI exhibited morphologic characteristics of mature DCs, expressed increased levels of CD1a, CD80, CD83, CD86, and MHC class II as well as enhanced ability to induce proliferation of alloreactive T cells isolated from cord blood and IFN-γ production. Treatment of CB-DCs with TNF-α or PMA + CI was less effective. Thus, Bryo-1 + CI promotes maturation of CB-DCs and therefore could be used to enhance the neonatal immune response.
URI
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DOI
10.1016/j.cellimm.2004.11.003
ISSN
0008-8749
Appears in Collections:
BME_Journal Papers
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