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Bae, Sung Chul
Multiscale Optical Imaging Lab
Research Interests
  • Multiscale optical imaging, laser spectroscopy, laser microscopy, laser sensing, soft matter physics, surface and interfacial science, laser Matter Interaction

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Biomolecular Science of Liposome-Nanoparticle Constructs

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Title
Biomolecular Science of Liposome-Nanoparticle Constructs
Author
Yu, YanAnthony, Stephen M.Bae, Sung ChulLuijten, ErikGranick, Steve
Issue Date
2009-01
Publisher
TAYLOR & FRANCIS LTD
Citation
MOLECULAR CRYSTALS AND LIQUID CRYSTALS, v.507, pp.18 - 25
Abstract
Phospholipid-nanoparticle constructs, formed by allowing nanoparticles to adsorb to the outer leaflet of liposomes, are found to be stabilized against fusion with one another. Here, through single-particle tracking by epifluorescence microscopy, we explore their use as novel colloidal particles-flexible and hollow colloidal particles that contrast strikingly with colloids of the conventional type. At the single-liposome level, the distribution of diffusion coefficients is quantified. Biomolecular function is addressed through experiments in which we explore the access of receptor to liposome-immobilized ligand, finding that receptor binding persists over a range of nanoparticle surface coverage where liposome fusion and large-scale aggregation is prevented. This opens the door to designing newer and more flexible types of tailor-made materials with desirable functionality.
URI
https://scholarworks.unist.ac.kr/handle/201301/7038
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=70349606818
DOI
10.1080/15421400903048024
ISSN
1542-1406
Appears in Collections:
CHM_Journal Papers
BME_Journal Papers
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