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Kwak, Ja Hun
Molecular Catalysis lab
Research Interests
  • Heterogeneous catalysis, molecular catalysis, ASlumima, zeolites

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A magnetically separable, highly stable enzyme system based on nanocomposites of enzymes and magnetic nanoparticles shipped in hierarchically ordered, mesocellular, mesoporous silica

Cited 70 times inthomson ciCited 70 times inthomson ci
Title
A magnetically separable, highly stable enzyme system based on nanocomposites of enzymes and magnetic nanoparticles shipped in hierarchically ordered, mesocellular, mesoporous silica
Author
Kim, JungbaeLee, JinwooNa, Hyon BinKim, Byoung ChanYoun, Jong KyuKwak, JahunMoon, KaramLee, EunwoongKim, JaeyunPark, JongnamDohnalkova, AlicePark, Hyun GyuGu, Man BockChang, Ho NamGrate, Jay W.Hyeon, Taeghwan
Issue Date
2005-12
Publisher
WILEY-V C H VERLAG GMBH
Citation
SMALL, v.1, no.12, pp.1203 - 1207
Abstract
The development of a magnetically separable and highly stable enzyme system, using nanoparticles and mesoporous silica, was investigated. Nanometer-scale composites of enzyme molecules and hierarchically ordered magnetite nanoparticles were immobilized via a ship-in-a-bottle approach, which used co-adsorption of enzymes and magnetite (Fe3O4) nanoparticles. The enzyme molecules were crosslinked via glutaraldehyde (GA) treatment resulting in the effective entrapment of neighboring magnetite nanoparticles. These nanocomposites, called M-CLEAs, were found magnetically separable, highly loaded with enzymes, stable under harsh conditions, resistant to proteolytic digestion, and recyclable for iterative use with negligible loss of enzyme activity. The ship-in-a-bottle approach can be expanded to many other enzymes and has applications in bioremediation and bioconversion.
URI
https://scholarworks.unist.ac.kr/handle/201301/6942
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33745433839
DOI
10.1002/smll.200500245
ISSN
1613-6810
Appears in Collections:
BME_Journal Papers
ECHE_Journal Papers
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