BROWSE

Related Researcher

Author's Photo

Kwak, Sang Kyu
Kyu’s MolSim Lab @ UNIST
Research Interests
  • Molecular modeling and simulation, statistical thermodynamics, molecular physics

ITEM VIEW & DOWNLOAD

Preparation of quantum dot/drug nanoparticle formulations for traceable targeted delivery and therapy

Cited 16 times inthomson ciCited 15 times inthomson ci
Title
Preparation of quantum dot/drug nanoparticle formulations for traceable targeted delivery and therapy
Author
Yong, Ken-TyeWang, YuchengRoy, IndrajitRui, HuSwihart, Mark T.Law, Wing-CheungKwak, Sang KyuYe, LingLiu, JianweiMahajan, Supriya D.Reynolds, Jessica L.
Keywords
Drug nanoparticle formulations; Quantum dots; Targeted delivery
Issue Date
2012-07
Publisher
IVYSPRING INT PUBL
Citation
THERANOSTICS, v.2, no.7, pp.681 - 694
Abstract
Quantum dots (QDs) are luminescent nanocrystals with rich surface chemistry and unique optical properties that make them useful as probes or carriers for traceable targeted delivery and therapy applications. QDs can be functionalized to target specific cells or tissues by conjugating them with targeting ligands. Recent advancement in making biocompatible QD formulations has made these nanocrystals suitable for in vivo applications. This review provides an overview of the preparation of QDs and their use as probes or carriers for traceable, targeted therapy of diseases in vitro and in vivo. More specifically, recent advances in the integration of QDs with drug formulations for therapy and their potential toxicity in vitro and in vivo are highlighted. The current findings and challenges for optimizing QD/drug formulations with respect to optimal size and stability, short-term and longterm toxicity, and in vivo applications are described. Lastly, we attempt to predict key trends in QD/drug formulation development over the next few years and highlight areas of therapy where their use may provide breakthrough results in the near future.
URI
https://scholarworks.unist.ac.kr/handle/201301/6829
DOI
10.7150/thno.3692
ISSN
1838-7640
Appears in Collections:
ECHE_Journal Papers
Files in This Item:
2-s2.0-84864410596.pdf Download

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qrcode

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU