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Lee, Sung Kuk
Synthetic Biology & Metabolic Engineering Laboratory
Research Interests
  • Biofuels production
  • Gene discovery
  • Protein engineering
  • Development of gene expression systems
  • Metabolic pathway regulation
  • Metabolic pathway optimization using functional genomics
  • Synthetic biology
  • Development of biosensors

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A novel family of retrotransposons in Xenopus with a developmentally regulated expression

Cited 6 times inthomson ciCited 6 times inthomson ci
Title
A novel family of retrotransposons in Xenopus with a developmentally regulated expression
Author
Shim, SLee, Sung KukHan, JK
Keywords
Embryo; Pattern formation; Retrotransposon; Xenopus; Zinc finger
Issue Date
2000-03
Publisher
WILEY-BLACKWELL
Citation
GENESIS, v.26, no.3, pp.198 - 207
Abstract
We have obtained a novel family of LTR-retrotransposons in Xenopus laevis, named Xretpos, from cDNA and genomic clones. Its long terminal repeats (LTRs) can be subdivided into U3, R, and U3 to U5 region, and are bounded by 6 bp inverted repeats. Xretpos contains primer binding site and polypurine tract, and multiple copies of Xretpos-related element are present in the genome. A long open reading frame (ORF) encodes the CCHC motif conserved in retroviral gag proteins and leucine zipper motif capable of forming the coiled-coil. However, no amino acid homology to usually conserved retroviral pol gene was revealed. We report that in vitro synthesized Xretpos complementary RNAs are translated to produce a predicted size of protein. We also show that zygotically activated Xretpos transcripts are restricted to ventro-posterior specific regions and induced by UV-irradiation and BMP-4 overexpression in cycloheximide-dependent way.
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DOI
10.1002/(SICI)1526-968X(200003)26:3<198::AID-GENE5>3.0.CO;2-0
ISSN
1526-954X
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ECHE_Journal Papers
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