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Lee, Sung Kuk
Synthetic Biology & Metabolic Engineering Laboratory
Research Interests
  • Biofuels production
  • Gene discovery
  • Protein engineering
  • Development of gene expression systems
  • Metabolic pathway regulation
  • Metabolic pathway optimization using functional genomics
  • Synthetic biology
  • Development of biosensors

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Metabolic engineering of microorganisms for biofuels production: from bugs to synthetic biology to fuels

Cited 207 times inthomson ciCited 213 times inthomson ci
Title
Metabolic engineering of microorganisms for biofuels production: from bugs to synthetic biology to fuels
Author
Lee, Sung KukChou, HowardHam, Timothy S.Lee, Taek SoonKeasling, Jay D.
Keywords
ESCHERICHIA-COLI; SACCHAROMYCES-CEREVISIAE; ISOPROPANOL PRODUCTION; XYLOSE FERMENTATION; ETHANOL-PRODUCTION; HIGHER ALCOHOLS; FLUX ANALYSIS; GENOME; MICROBES; PATHWAY
Issue Date
2008-12
Publisher
CURRENT BIOLOGY LTD
Citation
CURRENT OPINION IN BIOTECHNOLOGY, v.19, no.6, pp.556 - 563
Abstract
The ability to generate microorganisms that can produce biofuels similar to petroleum-based transportation fuels would allow the use of existing engines and infrastructure and would save an enormous amount of capital required for replacing the current infrastructure to accommodate biofuels that have properties significantly different from petroleum-based fuels. Several groups have demonstrated the feasibility of manipulating microbes to produce molecules similar to petroleum-derived products, albeit at relatively low productivity (e.g. maximum butanol production is around 20 g/L. For cost-effective production of biofuels, the fuel-producing hosts and pathways must be engineered and optimized. Advances in metabolic engineering and synthetic biology will provide new tools for metabolic engineers to better understand how to rewire the cell in order to create the desired phenotypes for the production of economically viable biofuels.
URI
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DOI
10.1016/j.copbio.2008.10.014
ISSN
0958-1669
Appears in Collections:
ECHE_Journal Papers
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