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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 559 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 545 | - |
dc.citation.title | CANCER RESEARCH | - |
dc.citation.volume | 84 | - |
dc.contributor.author | Kim, Sahee | - |
dc.contributor.author | Oh, Jiyoung | - |
dc.contributor.author | Park, Chanho | - |
dc.contributor.author | Kim, Min | - |
dc.contributor.author | Jo, Woobeen | - |
dc.contributor.author | Kim, Chu-Sook | - |
dc.contributor.author | Cho, Sun Wook | - |
dc.contributor.author | Park, Jiyoung | - |
dc.date.accessioned | 2023-12-21T16:05:11Z | - |
dc.date.available | 2023-12-21T16:05:11Z | - |
dc.date.created | 2023-12-21 | - |
dc.date.issued | 2024-02 | - |
dc.description.abstract | Adipose tissue within the tumor microenvironment (TME) plays a critical role in supporting breast cancer progression. In this study, we identified FAM3 metabolism-regulating signaling molecule C (FAM3C) produced by cancer-associated adipocytes (CAAs) as a key regulator of tumor progression. FAM3C overexpression in cultured adipocytes significantly reduced cell death in both adipocytes and co-cultured breast cancer cells while suppressing markers of fibrosis. Conversely, FAM3C depletion in CAAs resulted in adipocyte-mesenchymal transition (AMT) and increased fibrosis within the TME. Adipocyte FAM3C expression was driven by TGF-β signaling from breast cancer cells and was reduced upon treatment with a TGF-β-neutralizing antibody. FAM3C knockdown in CAAs early in tumorigenesis in a genetically engineered mouse model of breast cancer significantly inhibited primary and metastatic tumor growth. Circulating FAM3C levels were elevated in patients with metastatic breast cancer compared to those with non-metastatic breast cancer. These results suggest that therapeutic inhibition of FAM3C expression levels in CAAs during early tumor development could be a promising approach in the treatment of patients with breast cancer. | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH, v.84, no.4, pp.545 - 559 | - |
dc.identifier.doi | 10.1158/0008-5472.CAN-23-1641 | - |
dc.identifier.issn | 0008-5472 | - |
dc.identifier.scopusid | 2-s2.0-85185219775 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/66684 | - |
dc.identifier.wosid | 001163685000007 | - |
dc.language | 영어 | - |
dc.publisher | American Association for Cancer Research | - |
dc.title | FAM3C in cancer-associated adipocytes promotes breast cancer cell survival and metastasis | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalResearchArea | Oncology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | TGF-BETA | - |
dc.subject.keywordPlus | MESENCHYMAL TRANSITION | - |
dc.subject.keywordPlus | TUMOR MICROENVIRONMENT | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | ILEI | - |
dc.subject.keywordPlus | EMT | - |
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