File Download

  • Find it @ UNIST can give you direct access to the published full text of this article. (UNISTARs only)
Related Researcher

GartnerAnton

Gartner, Anton
DNA Damage Response and Genetic Toxicology
Read More

Views & Downloads

Detailed Information

Cited time in webofscience Cited time in scopus
Metadata Downloads

Full metadata record

DC Field Value Language
dc.citation.endPage 224.e8 -
dc.citation.number 1 -
dc.citation.startPage 212 -
dc.citation.title CELL REPORTS -
dc.citation.volume 29 -
dc.contributor.author Bailly, Aymeric P. -
dc.contributor.author Perrin, Aurelien -
dc.contributor.author Serrano-Macia, Marina -
dc.contributor.author Maghames, Chantal -
dc.contributor.author Leidecker, Orsolya -
dc.contributor.author Trauchessec, Helene -
dc.contributor.author Martinez-Chantar, M.L. -
dc.contributor.author Gartner, Anton -
dc.contributor.author Xirodimas, Dimitris P. -
dc.date.accessioned 2023-12-21T18:36:49Z -
dc.date.available 2023-12-21T18:36:49Z -
dc.date.created 2023-09-21 -
dc.date.issued 2019-10 -
dc.description.abstract Ubiquitin and ubiquitin-like chains are finely balanced by conjugating and de-conjugating enzymes. Alterations in this balance trigger the response to stress conditions and are often observed in pathologies. How such changes are detected is not well understood. We identify the HSP70 chaperone as a sensor of changes in the balance between mono- and poly-NEDDylation. Upon DNA damage, the induction of the de-NEDDylating enzyme NEDP1 restricts the formation of NEDD8 chains, mainly through lysines K11/K48. This promotes APAF1 oligomerization and apoptosis induction, a step that requires the HSP70 ATPase activity. HSP70 binds to NEDD8, and, in vitro, the conversion of NEDD8 chains into mono-NEDD8 stimulates HSP70 ATPase activity. This effect is independent of NEDD8 conjugation onto substrates. The study indicates that the NEDD8 cycle is a regulatory module of HSP70 function. These findings may be important in tumorigenesis, as we find decreased NEDP1 levels in hepatocellular carcinoma with concomitant accumulation of NEDD8 conjugates. -
dc.identifier.bibliographicCitation CELL REPORTS, v.29, no.1, pp.212 - 224.e8 -
dc.identifier.doi 10.1016/j.celrep.2019.08.070 -
dc.identifier.issn 2211-1247 -
dc.identifier.scopusid 2-s2.0-85072584225 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/65728 -
dc.identifier.wosid 000488614600017 -
dc.language 영어 -
dc.publisher Cell Press -
dc.title The Balance between Mono- and NEDD8-Chains Controlled by NEDP1 upon DNA Damage Is a Regulatory Module of the HSP70 ATPase Activity -
dc.type Article -
dc.description.isOpenAccess TRUE -
dc.type.docType Article -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.subject.keywordAuthor APAF1 -
dc.subject.keywordAuthor apoptosis -
dc.subject.keywordAuthor C. elegans -
dc.subject.keywordAuthor DNA damage -
dc.subject.keywordAuthor hepatocellular carcinoma -
dc.subject.keywordAuthor HSP70 -
dc.subject.keywordAuthor K11/K48 chains -
dc.subject.keywordAuthor NEDD8 -
dc.subject.keywordAuthor NEDP1/SENP8 -
dc.subject.keywordAuthor proteomics -

qrcode

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.