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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 33 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 28 | - |
dc.citation.title | Electrolyte and Blood Pressure | - |
dc.citation.volume | 5 | - |
dc.contributor.author | Jung, Ju-Young | - |
dc.contributor.author | Kwon, Hyug Moo | - |
dc.contributor.author | Kim, Jim | - |
dc.date.accessioned | 2023-12-22T09:12:54Z | - |
dc.date.available | 2023-12-22T09:12:54Z | - |
dc.date.created | 2023-07-10 | - |
dc.date.issued | 2007-06 | - |
dc.description.abstract | Urea accumulation in the renal inner medulla plays a key role in the maintenance of maximal urinary concentrating ability. Urea transport in the kidney is mediated by transporter proteins that include renal urea transporter (UT-A) and erythrocyte urea transporter (UT-B). UT-A1 and UT-A2 are produced from the same gene. There is an active tonicity-responsive enhancer (TonE) in the promoter of UT-A1, and the UT-A1 promoter is stimulated by hypertonicity via tonicity-responsive enhancer binding protein (TonEBP). The downregulation of UT-A2 raises the possibility that TonEBP also regulates its promoter. There is some evidence that TonEBP regulates expression of UT-A in vivo; (1) during the renal development of the urinary concentrating ability, expression of TonEBP precedes that of UT-A1; (2) in transgenic mice expressing a dominant negative form of TonEBP, expression of UT-A1 and UT-A2 is severely impaired; (3) in treatment with cyclosporine A, TonEBP was significantly downregulated after 28 days. This downregulation involves mRNA levels of UT-A2; (4) in hypokalemic animals, downregulation of TonEBP contributed to the down regulation of UT-A in the inner medulla. These data support that TonEBP directly contributes to the urinary concentration and renal urea recycling by the regulation of urea transporters. | - |
dc.identifier.bibliographicCitation | Electrolyte and Blood Pressure, v.5, no.1, pp.28 - 33 | - |
dc.identifier.doi | 10.5049/EBP.2007.5.1.28 | - |
dc.identifier.issn | 1738-5997 | - |
dc.identifier.scopusid | 2-s2.0-34250867305 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/64814 | - |
dc.language | 영어 | - |
dc.publisher | Korean Society of Electrolyte and Blood Pressure Research | - |
dc.title | Regulation of urea transporters by tonicity-responsive enhancer binding protein | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.type.docType | Review | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.description.journalRegisteredClass | kci_candi | - |
dc.subject.keywordAuthor | Tonicity-responsive enhancer binding protein | - |
dc.subject.keywordAuthor | Urea transporters | - |
dc.subject.keywordAuthor | Urine concentration | - |
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