There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 5602 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 5584 | - |
dc.citation.title | NUCLEIC ACIDS RESEARCH | - |
dc.citation.volume | 51 | - |
dc.contributor.author | Oh, Jung-Min | - |
dc.contributor.author | Kang, Yujin | - |
dc.contributor.author | Park, Jumi | - |
dc.contributor.author | Sung, Yubin | - |
dc.contributor.author | Kim, Dayoung | - |
dc.contributor.author | Seo, Yuri | - |
dc.contributor.author | Lee, EunA | - |
dc.contributor.author | Ra, JaeSun | - |
dc.contributor.author | Amarsanaa, Enkhzul | - |
dc.contributor.author | Park, Young-Un | - |
dc.contributor.author | Lee, SeonYoung | - |
dc.contributor.author | Hwang, JungMe | - |
dc.contributor.author | Kim, Hongtae | - |
dc.contributor.author | Scharer, Orlando D. | - |
dc.contributor.author | Cho, Seung Woo | - |
dc.contributor.author | Lee, Changwook | - |
dc.contributor.author | Takata, Kei-ichi | - |
dc.contributor.author | Lee, Ja Yil | - |
dc.contributor.author | Myung, Kyungjae | - |
dc.date.accessioned | 2023-12-21T12:37:29Z | - |
dc.date.available | 2023-12-21T12:37:29Z | - |
dc.date.created | 2023-06-07 | - |
dc.date.issued | 2023-06 | - |
dc.description.abstract | DNA double-strand break (DSB) repair via homologous recombination is initiated by end resection. The extent of DNA end resection determines the choice of the DSB repair pathway. Nucleases for end resection have been extensively studied. However, it is still unclear how the potential DNA structures generated by the initial short resection by MRE11-RAD50-NBS1 are recognized and recruit proteins, such as EXO1, to DSB sites to facilitate long-range resection. We found that the MSH2-MSH3 mismatch repair complex is recruited to DSB sites through interaction with the chromatin remodeling protein SMARCAD1. MSH2-MSH3 facilitates the recruitment of EXO1 for long-range resection and enhances its enzymatic activity. MSH2-MSH3 also inhibits access of POL theta, which promotes polymerase theta-mediated end-joining (TMEJ). Collectively, we present a direct role of MSH2-MSH3 in the initial stages of DSB repair by promoting end resection and influencing the DSB repair pathway by favoring homologous recombination over TMEJ. | - |
dc.identifier.bibliographicCitation | NUCLEIC ACIDS RESEARCH, v.51, no.11, pp.5584 - 5602 | - |
dc.identifier.doi | 10.1093/nar/gkad308 | - |
dc.identifier.issn | 0305-1048 | - |
dc.identifier.scopusid | 2-s2.0-85163797535 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/64405 | - |
dc.identifier.wosid | 000981054000001 | - |
dc.language | 영어 | - |
dc.publisher | Oxford University Press (OUP) | - |
dc.title | MSH2-MSH3 promotes DNA end resection during homologous recombination and blocks polymerase theta-mediated end-joining through interaction with SMARCAD1 and EXO1 | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | MUTS-BETA | - |
dc.subject.keywordPlus | HETERODUPLEX REJECTION | - |
dc.subject.keywordPlus | SGS1 HELICASE | - |
dc.subject.keywordPlus | INSTABILITY | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordPlus | ALPHA | - |
dc.subject.keywordPlus | MISMATCH REPAIR PROTEINS | - |
dc.subject.keywordPlus | STRAND BREAK REPAIR | - |
dc.subject.keywordPlus | SACCHAROMYCES-CEREVISIAE MSH2 | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.