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Lee, Dong Woog
Interfacial Physics and Chemistry Lab.
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dc.citation.endPage 2642 -
dc.citation.number 6 -
dc.citation.startPage 2633 -
dc.citation.title BIOMACROMOLECULES -
dc.citation.volume 24 - Gye, Hyeryeong - Baek, Heeyeon - Han, Seunghyun - Kwon, Haeun - Nguyen, Trang Vu Thien - Pham, Le Thanh Mai - Kang, Seunghyun - Nho, Youn Hwa - Lee, Dong Woog - Kim, Yong Hwan - 2023-12-21T12:37:51Z - 2023-12-21T12:37:51Z - 2023-04-24 - 2023-06 -
dc.description.abstract Recently, the desire for a safe and effective method for skin whitening has been growing in the cosmetics industry. Commonly used tyrosinase-inhibiting chemical reagents exhibit side effects. Thus, recent studies have focused on performing melanin decolorization with enzymes as an alternative due to the low toxicity of enzymes and their ability to decolorize melanin selectively. Herein, 10 different isozymes were expressed as recombinant lignin peroxidases (LiPs) from Phanerochaete chrysosporium (PcLiPs), and PcLiP isozyme 4 (PcLiP04) was selected due to its high stability and activity at pH 5.5 and 37 °C, which is close to human skin conditions. In vitro melanin decolorization results indicated that PcLiP04 exhibited at least 2.9-fold higher efficiency than that of well-known lignin peroxidase (PcLiP01) in a typical human skin-mimicking environment. The interaction force between melanin films measured by a surface forces apparatus (SFA) revealed that the decolorization of melanin by PcLiP04 harbors a disrupted structure, possibly interrupting π–π stacking and/or hydrogen bonds. In addition, a 3D reconstructed human pigmented epidermis skin model showed a decrease in melanin area to 59.8% using PcLiP04, which suggests that PcLiP04 exhibits a strong potential for skin whitening. -
dc.identifier.bibliographicCitation BIOMACROMOLECULES, v.24, no.6, pp.2633 - 2642 -
dc.identifier.doi 10.1021/acs.biomac.3c00123 -
dc.identifier.issn 1525-7797 -
dc.identifier.scopusid 2-s2.0-85158022541 -
dc.identifier.uri -
dc.identifier.url -
dc.identifier.wosid 000975065000001 -
dc.language 영어 -
dc.publisher American Chemical Society -
dc.title Recombinant lignin peroxidase with superior thermal stability and melanin decolorization efficiency in a typical human skin-mimicking environment -
dc.type Article -
dc.description.isOpenAccess FALSE -
dc.relation.journalWebOfScienceCategory Biochemistry & Molecular Biology;Chemistry, Organic;Polymer Science -
dc.relation.journalResearchArea Biochemistry & Molecular Biology;Chemistry;Polymer Science -
dc.type.docType Article -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -


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