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Kim, Jae-Ick
Neural Circuit and Neurodegenerative Disease Lab.
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dc.citation.endPage 55 -
dc.citation.number 1 -
dc.citation.startPage 42 -
dc.citation.volume 32 - Lee, Hyun-ju - Park, Jin-Hee - Trotter, Justin H. - Maher, James N. - Keenoy, Kathleen E. - Jang, You Mi - Lee, Youngeun - Kim, Jae-Ick - Weeber, Edwin J. - Hoe, Hyang-Sook - 2023-12-21T12:47:37Z - 2023-12-21T12:47:37Z - 2023-04-03 - 2023-03 -
dc.description.abstract Amyloid precursor protein (APP) plays an important role in the pathogenesis of Alzheimer’s disease (AD), but the normal function of APP at synapses is poorly understood. We and others have found that APP interacts with Reelin and that each protein is individually important for dendritic spine formation, which is associated with learning and memory, in vitro. However, whether Reelin acts through APP to modulate dendritic spine formation or synaptic function remains unknown. In the present study, we found that Reelin treatment significantly increased dendritic spine density and PSD-95 puncta number in primary hippocampal neurons. An examination of the molecular mechanisms by which Reelin regulates dendritic spinogenesis revealed that Reelin enhanced hippocampal dendritic spine formation in a Ras/ERK/CREB signaling-dependent manner. Interestingly, Reelin did not increase dendritic spine number in primary hippocampal neurons when APP expression was reduced or in vivo in APP knockout (KO) mice. Taken together, our data are the first to demonstrate that Reelin acts cooperatively with APP to modulate dendritic spine formation and suggest that normal APP function is critical for Reelin-mediated dendritic spinogenesis at synapses. -
dc.identifier.bibliographicCitation EXPERIMENTAL NEUROBIOLOGY, v.32, no.1, pp.42 - 55 -
dc.identifier.doi 10.5607/en22044 -
dc.identifier.issn 1226-2560 -
dc.identifier.uri -
dc.identifier.wosid 000958503600005 -
dc.language 영어 -
dc.publisher 한국뇌신경과학회 -
dc.title Reelin and APP Cooperatively Modulate Dendritic Spine Formation In Vitro and In Vivo -
dc.type Article -
dc.description.isOpenAccess TRUE -
dc.relation.journalWebOfScienceCategory Medicine, Research & Experimental;Neurosciences -
dc.relation.journalResearchArea Research & Experimental Medicine;Neurosciences & Neurology -
dc.type.docType Article -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.description.journalRegisteredClass kci -
dc.subject.keywordAuthor APP -
dc.subject.keywordAuthor Reelin -
dc.subject.keywordAuthor Dendritic spine -
dc.subject.keywordAuthor Alzheimer?s disease -
dc.subject.keywordAuthor Ras signaling -
dc.subject.keywordPlus AMYLOID-PRECURSOR-PROTEIN -
dc.subject.keywordPlus SYNAPTIC PLASTICITY -
dc.subject.keywordPlus COFILIN PHOSPHORYLATION -
dc.subject.keywordPlus MOUSE MODEL -
dc.subject.keywordPlus RECEPTOR -
dc.subject.keywordPlus NMDA -
dc.subject.keywordPlus RAS -
dc.subject.keywordPlus NEURONS -
dc.subject.keywordPlus ENHANCEMENT -
dc.subject.keywordPlus DISRUPTION -


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