Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 55 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 42 | - |
dc.citation.title | EXPERIMENTAL NEUROBIOLOGY | - |
dc.citation.volume | 32 | - |
dc.contributor.author | Lee, Hyun-ju | - |
dc.contributor.author | Park, Jin-Hee | - |
dc.contributor.author | Trotter, Justin H. | - |
dc.contributor.author | Maher, James N. | - |
dc.contributor.author | Keenoy, Kathleen E. | - |
dc.contributor.author | Jang, You Mi | - |
dc.contributor.author | Lee, Youngeun | - |
dc.contributor.author | Kim, Jae-Ick | - |
dc.contributor.author | Weeber, Edwin J. | - |
dc.contributor.author | Hoe, Hyang-Sook | - |
dc.date.accessioned | 2023-12-21T12:47:37Z | - |
dc.date.available | 2023-12-21T12:47:37Z | - |
dc.date.created | 2023-04-03 | - |
dc.date.issued | 2023-03 | - |
dc.description.abstract | Amyloid precursor protein (APP) plays an important role in the pathogenesis of Alzheimer’s disease (AD), but the normal function of APP at synapses is poorly understood. We and others have found that APP interacts with Reelin and that each protein is individually important for dendritic spine formation, which is associated with learning and memory, in vitro. However, whether Reelin acts through APP to modulate dendritic spine formation or synaptic function remains unknown. In the present study, we found that Reelin treatment significantly increased dendritic spine density and PSD-95 puncta number in primary hippocampal neurons. An examination of the molecular mechanisms by which Reelin regulates dendritic spinogenesis revealed that Reelin enhanced hippocampal dendritic spine formation in a Ras/ERK/CREB signaling-dependent manner. Interestingly, Reelin did not increase dendritic spine number in primary hippocampal neurons when APP expression was reduced or in vivo in APP knockout (KO) mice. Taken together, our data are the first to demonstrate that Reelin acts cooperatively with APP to modulate dendritic spine formation and suggest that normal APP function is critical for Reelin-mediated dendritic spinogenesis at synapses. | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL NEUROBIOLOGY, v.32, no.1, pp.42 - 55 | - |
dc.identifier.doi | 10.5607/en22044 | - |
dc.identifier.issn | 1226-2560 | - |
dc.identifier.scopusid | 2-s2.0-85153196036 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/62470 | - |
dc.identifier.wosid | 000958503600005 | - |
dc.language | 영어 | - |
dc.publisher | 한국뇌신경과학회 | - |
dc.title | Reelin and APP Cooperatively Modulate Dendritic Spine Formation In Vitro and In Vivo | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental;Neurosciences | - |
dc.relation.journalResearchArea | Research & Experimental Medicine;Neurosciences & Neurology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | APP | - |
dc.subject.keywordAuthor | Reelin | - |
dc.subject.keywordAuthor | Dendritic spine | - |
dc.subject.keywordAuthor | Alzheimer?s disease | - |
dc.subject.keywordAuthor | Ras signaling | - |
dc.subject.keywordPlus | AMYLOID-PRECURSOR-PROTEIN | - |
dc.subject.keywordPlus | SYNAPTIC PLASTICITY | - |
dc.subject.keywordPlus | COFILIN PHOSPHORYLATION | - |
dc.subject.keywordPlus | MOUSE MODEL | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | NMDA | - |
dc.subject.keywordPlus | RAS | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | ENHANCEMENT | - |
dc.subject.keywordPlus | DISRUPTION | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.