Full metadata record
DC Field | Value | Language |
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dc.citation.number | 3 | - |
dc.citation.startPage | 654 | - |
dc.citation.title | BIOMEDICINES | - |
dc.citation.volume | 11 | - |
dc.contributor.author | Jung, Inkyung | - |
dc.contributor.author | An, Jungeun | - |
dc.contributor.author | Ko, Myunggon | - |
dc.date.accessioned | 2023-12-21T13:07:16Z | - |
dc.date.available | 2023-12-21T13:07:16Z | - |
dc.date.created | 2023-02-22 | - |
dc.date.issued | 2023-02 | - |
dc.description.abstract | Epigenetic modifications are crucial regulators of gene expression that critically impact cell lineage differentiation, survival, and proliferation, and dysregulations are commonly observed in various cancers. The aberrantly modified epigenome confers unique features on tumor cells, including sustained proliferative potential, resistance to growth-suppressive or cell death signals, augmented replicative immortality, invasion, and metastasis. As a result, epigenetic abnormalities exhibit significant impacts on all stages of oncogenesis from its onset to progression to metastasis. Among various epigenetic mechanisms in mammals, DNA cytosine methylation–demethylation is recurrently disrupted in cancers. Due to its inherent reversibility, targeting DNA methylation dynamics has gained tremendous attention as a promising therapeutic option that can ameliorate the effects of cancer-specific epigenetic abnormalities by restoring normal conditions. Various small molecules targeting DNA (de)methylation regulators have been developed as potential cancer therapeutics, some of which are approved for usage in clinics. Clinical trials of many other molecules are underway for both hematological malignancies and solid tumors. In this review, we discuss the DNA methylation/demethylation pathway as a promising target for therapeutic intervention in cancer and highlight the development of various epigenetic drugs targeting DNA-modifying enzymes such as DNA methyltransferases (DNMTs) and ten-eleven translocation (TET) enzymes. | - |
dc.identifier.bibliographicCitation | BIOMEDICINES, v.11, no.3, pp.654 | - |
dc.identifier.doi | 10.3390/biomedicines11030654 | - |
dc.identifier.issn | 2227-9059 | - |
dc.identifier.scopusid | 2-s2.0-85151932423 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/61987 | - |
dc.identifier.wosid | 000957426700001 | - |
dc.language | 영어 | - |
dc.publisher | MDPI AG | - |
dc.title | Epigenetic Regulators of DNA Cytosine Modification: Promising Targets for Cancer Therapy | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology;Medicine, Research & Experimental;Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology;Research & Experimental Medicine;Pharmacology & Pharmacy | - |
dc.type.docType | Review | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | epigenetics | - |
dc.subject.keywordAuthor | DNMT | - |
dc.subject.keywordAuthor | TET dioxygenases | - |
dc.subject.keywordAuthor | DNA methylation and demethylation | - |
dc.subject.keywordAuthor | small molecules | - |
dc.subject.keywordAuthor | cancer therapy | - |
dc.subject.keywordPlus | RISK MYELODYSPLASTIC SYNDROME | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR GENES | - |
dc.subject.keywordPlus | ACUTE MYELOID-LEUKEMIA | - |
dc.subject.keywordPlus | CELL SELF-RENEWAL | - |
dc.subject.keywordPlus | VITAMIN-C | - |
dc.subject.keywordPlus | TET2 FUNCTION | - |
dc.subject.keywordPlus | PHASE-I | - |
dc.subject.keywordPlus | 5-METHYLCYTOSINE OXIDATION | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | METHYLATION | - |
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