A CMOS Microelectrode Array System With Reconfigurable Sub-Array Multiplexing Architecture Integrating 24,320 Electrodes and 380 Readout Channels
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- A CMOS Microelectrode Array System With Reconfigurable Sub-Array Multiplexing Architecture Integrating 24,320 Electrodes and 380 Readout Channels
- Cha, Ji-Hyoung; Park, Jee-Ho; Park, Yongjae; Shin, Hyogeun; Hwang, Kyeong Seob; Cho, Il-Joo; Kim, Seong-Jin
- Issue Date
- Institute of Electrical and Electronics Engineers
- IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS, v.16, no.6, pp.1044 - 1056
- This article presents a CMOS microelectrode array (MEA) system with a reconfigurable sub-array multiplexing architecture using the time-division multiplexing (TDM) technique. The system consists of 24,320 TiN electrodes with 17.7 µm-pitch pixels and 380 column-parallel readout channels including a low-noise amplifier, a programmable gain amplifier, and a 10-b successive approximation register analog to digital converter. Readout channels are placed outside the pixel for high spatial resolution, and a flexible structure to acquire neural signals from electrodes selected by configuring in-pixel memory is realized. In this structure, a single channel can handle 8 to 32 electrodes, guaranteeing a temporal resolution from 5kS/s to 20kS/s for each electrode. A 128 × 190 MEA system was fabricated in a 110-nm CMOS process, and each readout channel consumes 81 µW at 1.5-V supply voltage featuring input-referred noise of 1.48 µVrms without multiplexing and 5.4 µVrms with multiplexing at the action-potential band (300 Hz – 10 kHz).
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