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강세병

Kang, Sebyung
Protein Nanobio Lab.
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dc.citation.endPage 5201 -
dc.citation.number 12 -
dc.citation.startPage 5193 -
dc.citation.title BIOMACROMOLECULES -
dc.citation.volume 23 -
dc.contributor.author Lee, Kangseok -
dc.contributor.author Noh, Yeongjin -
dc.contributor.author Bae, Yoonji -
dc.contributor.author Kang, Sebyung -
dc.contributor.author Cha, Chaenyung -
dc.date.accessioned 2023-12-21T13:14:10Z -
dc.date.available 2023-12-21T13:14:10Z -
dc.date.created 2022-12-05 -
dc.date.issued 2022-12 -
dc.description.abstract With the continued advancement in the design and engineering of hydrogels for biomedical applications, there is a growing interest in imparting stimuli-responsiveness to the hydrogels in order to control their physicomechanical properties in a more programmable manner. In this study, an in situ forming hydrogel is developed by cross-linking alginate with an elastin-like polypeptide (ELP). Lysine-rich ELP synthesized by recombinant DNA technology is reacted with alginate presenting an aldehyde via Schiff base formation, resulting in facile hydrogel formation under physiological conditions. The physicomechanical properties of alginate-ELP hydrogels can be controlled in a wide range by the concentrations of alginate and ELP. Owing to the thermoresponsive properties of the ELP, the alginate-ELP hydrogels undergo swelling/deswelling near the physiological temperature. Taking advantage of these highly attractive properties of alginate-ELP, drug release kinetics were measured to evaluate their potential as a thermoresponsive drug delivery system. Furthermore, an ex vivo model was used to demonstrate the minimally invasive tissue injectability. -
dc.identifier.bibliographicCitation BIOMACROMOLECULES, v.23, no.12, pp.5193 - 5201 -
dc.identifier.doi 10.1021/acs.biomac.2c01001 -
dc.identifier.issn 1525-7797 -
dc.identifier.scopusid 2-s2.0-85142157391 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/60099 -
dc.identifier.url https://pubs.acs.org/doi/10.1021/acs.biomac.2c01001 -
dc.identifier.wosid 000886217500001 -
dc.language 영어 -
dc.publisher AMER CHEMICAL SOC -
dc.title Tunable Physicomechanical and Drug Release Properties of In Situ Forming Thermoresponsive Elastin-like Polypeptide Hydrogels -
dc.type Article -
dc.description.isOpenAccess FALSE -
dc.relation.journalWebOfScienceCategory Biochemistry & Molecular Biology; Chemistry, Organic; Polymer Science -
dc.relation.journalResearchArea Biochemistry & Molecular Biology; Chemistry; Polymer Science -
dc.type.docType Article; Early Access -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.subject.keywordPlus OXIDIZED ALGINATE -
dc.subject.keywordPlus DELIVERY -
dc.subject.keywordPlus DEGRADATION -
dc.subject.keywordPlus TRANSITION -
dc.subject.keywordPlus BEHAVIOR -

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