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Kang, Seok Ju
Smart Materials for Energy Lab.
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Photoswitchable Microgels for Dynamic Macrophage Modulation

Author(s)
Kim, YuriThangam, RamarYoo, JounghyunHeo, JeongyunPark, Jung YeonKang, NayeonLee, SungkyuYoon, JiwonMun, Kwang RokKang, MisunMin, SunhongKim, Seong YeolSon, SubinKim, JihwanHong, HyunsikBae, GunhyuKim, KanghyeonLee, SanghyeokYang, LetaoLee, Ja YeonKim, JinjooPark, SteveKim, Dong-HyunLee, Ki-BumJang, Woo YoungKim, Bong HoonPaulmurugan, RamasamyCho, Seung-WooSong, Hyun-CheolKang, Seok JuSun, WujinZhu, YangzhiLee, JunminKim, Han-JunJang, Ho SeongKim, Jong SeungKhademhosseini, AliKim, YongjuKim, SehoonKang, Heemin
Issued Date
2022-12
DOI
10.1002/adma.202205498
URI
https://scholarworks.unist.ac.kr/handle/201301/60056
Fulltext
https://onlinelibrary.wiley.com/doi/10.1002/adma.202205498
Citation
ADVANCED MATERIALS, v.34, no.49, pp.2205498
Abstract
Dynamic manipulation of supramolecular self-assembled structures is achieved irreversibly or under non-physiological conditions, thereby limiting their biomedical, environmental, and catalysis applicability. In this study, microgels composed of azobenzene derivatives stacked via pi-cation and pi-pi interactions are developed that are electrostatically stabilized with Arg-Gly-Asp (RGD)-bearing anionic polymers. Lateral swelling of RGD-bearing microgels occurs via cis-azobenzene formation mediated by near-infrared-light-upconverted ultraviolet light, which disrupts intermolecular interactions on the visible-light-absorbing upconversion-nanoparticle-coated materials. Real-time imaging and molecular dynamics simulations demonstrate the deswelling of RGD-bearing microgels via visible-light-mediated trans-azobenzene formation. Near-infrared light can induce in situ swelling of RGD-bearing microgels to increase RGD availability and trigger release of loaded interleukin-4, which facilitates the adhesion structure assembly linked with pro-regenerative polarization of host macrophages. In contrast, visible light can induce deswelling of RGD-bearing microgels to decrease RGD availability that suppresses macrophage adhesion that yields pro-inflammatory polarization. These microgels exhibit high stability and non-toxicity. Versatile use of ligands and protein delivery can offer cytocompatible and photoswitchable manipulability of diverse host cells.
Publisher
WILEY-V C H VERLAG GMBH
ISSN
0935-9648
Keyword (Author)
dynamic hydrogelsmacrophage adhesionmacrophage polarizationmicrogel swellingphotoswitchable microgels
Keyword
UP-CONVERSIONCELL-ADHESIONPOLARIZATIONINFLAMMATION

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