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Cho, Hyungjoon
Biomedical Imaging Science and Engineering Lab(BISE)
Research Interests
  • Imaging tumor microenvironments, susceptibility contrast based MR structural imaging, ultra fast acquisitions of dynamic MR, algorithm/Hardware development for magnetic particle imaging

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User-designed device with programmable release profile for localized treatment

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Title
User-designed device with programmable release profile for localized treatment
Author
Myung, NohyunJin, SeokhaCho, HyungjoonKang, Hyun-Wook
Issue Date
2022-11
Publisher
Elsevier BV
Citation
JOURNAL OF CONTROLLED RELEASE, v.352, pp.685 - 699
Abstract
Three-dimensional printing enables precise and on-demand manufacture of customizable drug delivery systems to advance healthcare toward the goal of personalized medicine. However, major challenges remain in realizing personalized drug delivery that fits a patient-specific drug dosing schedule using local drug delivery systems. In this study, a user-designed device is developed as implantable therapeutics that can realize personalized drug release kinetics by programming the inner structural design on the microscale. The drug release kinetics required for various treatments, including dose-dense therapy and combination therapy, can be implemented by controlling the dosage and combination of drugs along with the rate, duration, initiation time, and time interval of drug release according to the device layer design. After implantation of the capsular device in mice, the in vitro–in vivo and pharmacokinetic evaluation of the device is performed, and the therapeutic effect of the developed device is achieved through the local release of doxorubicin. The developed user-designed device provides a novel platform for developing next-generation drug delivery systems for personalized and localized therapy.
URI
https://scholarworks.unist.ac.kr/handle/201301/59988
DOI
10.1016/j.jconrel.2022.10.054
ISSN
0168-3659
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BME_Journal Papers
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