Preparation of Giant Quantum Dot-Liposome Complexes by the Asolectin Lipid and Theoretical Model for Stabilization of Nanoparticle Inside the Liposome

Abstract

We prepare giant Quantum dot-Liposome Complexes (QLCs). Quantum dots (QDs) incorporated inside liposome above 10 mu m. QLCs is made by using the electro-swelling method combined with spin coating techniques. Three types of PC lipids and asolectin lipid are used for QLCs with HDA (hexadecylamine) coated QDs, which ranged from blue-(diameter-2.1 nm) to red-emission (diam-eter-5.0 nm). As expected, (blue-or) green-emission QDs (smaller than) comparable to the thick-ness of PC lipid bilayer (-4 nm) are successfully formed QLCs, but QDs bigger than that fail to reproduce. This observation is well-consistent with those reported by Gopakumar et al. Surprisingly, all QDs irrespective of their size are, contrary to PC lipids, successfully loaded into asolectin lipid IP: 203.8.109.20 On: Thu, 11 Aug 2022 08:59:06 bilayer. In order to understand what makes different behaviors between PC and asolectin lipids on Copyright: American Scientific Publishers QLC formation, we suggest a theoretical model based on a geometrical assumptions for deformed Delivered by Ingenta lipid bilayer surrounding QD. The main advantage of this model is that the critical size Rcr of QD radius can be decided without calculating elastic free energy. As a result, it predicts that only QDs below the critical size (diameter-3.0 nm) can be loaded in a typical PC-lipid, but all size of QDs can be incorporated into asolectin bilayer under the assumption of two different curvatures on deformed monolayer.