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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 34 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 29 | - |
dc.citation.title | MOLECULES AND CELLS | - |
dc.citation.volume | 14 | - |
dc.contributor.author | Kim, Hongtae | - |
dc.contributor.author | Kim, JY | - |
dc.contributor.author | Kim, KA | - |
dc.contributor.author | Lim, Y | - |
dc.contributor.author | Kim, YH | - |
dc.contributor.author | Huh, PW | - |
dc.contributor.author | Lee, KH | - |
dc.contributor.author | Han, H | - |
dc.contributor.author | Wang, YP | - |
dc.contributor.author | Rha, HK | - |
dc.date.accessioned | 2023-12-22T11:37:13Z | - |
dc.date.available | 2023-12-22T11:37:13Z | - |
dc.date.created | 2022-10-17 | - |
dc.date.issued | 2002-08 | - |
dc.description.abstract | Recently we cloned the phospholipase C delta1 (PLC-delta1) promoter region and found that PLC-delta1 is selectively expressed in several tissues. In order to establish the common and cell-type specific transcriptional elements, 1.8 kilobase of the 5'-flanking. region of PLC-delta1 was characterized in several cell lines. A transient transfection assay of the -1787-Luc construct in several cell lines demonstrated the potential transcriptional enhancement of reporter activities in the neuroblastoma cell [SK-N-BE(2)C] and kidney cell lines (Cos-7), but not in liver cell lines (Chang liver cell). Transient transfection assays of a series of 5' --> 3' deletion constructs of the PLC-delta1 promoter and electronic mobility shift assays suggested that the E-box and HFH3 binding sites are cell-type specific elements, and that Sp-1 is a major transcriptional activator of a majority of cell lines. Our findings, therefore, indicate that the combination of several elements within the 5'-flanking region of the PLC-delta1 gene dictates its restricted expression in several cell lines. | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.14, no.1, pp.29 - 34 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.scopusid | 2-s2.0-17144459657 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/59775 | - |
dc.identifier.wosid | 000177772900005 | - |
dc.language | 영어 | - |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | - |
dc.title | Identification of the elements regulating the expression of the phospholipase C delta1 | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Cell Biology | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Cell Biology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | cell type specific | - |
dc.subject.keywordAuthor | E-box | - |
dc.subject.keywordAuthor | HFH3 | - |
dc.subject.keywordAuthor | PLC-delta 1 | - |
dc.subject.keywordAuthor | Sp-1 | - |
dc.subject.keywordPlus | BETA-GAMMA-SUBUNITS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | C-DELTA-1 | - |
dc.subject.keywordPlus | CLONING | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | BETA2/NEUROD | - |
dc.subject.keywordPlus | MYOGENESIS | - |
dc.subject.keywordPlus | MESSENGER | - |
dc.subject.keywordPlus | EFFECTOR | - |
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