There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 1302 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1295 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 296 | - |
dc.contributor.author | Kim, JY | - |
dc.contributor.author | Kim, Hongtae | - |
dc.contributor.author | Jeun, SS | - |
dc.contributor.author | Rha, SJ | - |
dc.contributor.author | Kim, YH | - |
dc.contributor.author | Ko, YJ | - |
dc.contributor.author | Won, J | - |
dc.contributor.author | Lee, KH | - |
dc.contributor.author | Rha, HK | - |
dc.contributor.author | Wang, YP | - |
dc.date.accessioned | 2023-12-22T11:36:53Z | - |
dc.date.available | 2023-12-22T11:36:53Z | - |
dc.date.created | 2022-10-17 | - |
dc.date.issued | 2002-09 | - |
dc.description.abstract | The neurofibromatosis type 2 (NF2) gene encodes an ezrin-radixin-moesin (ERM) related protein, referred to as either merlin or schwannomin, that is known to be a tumor suppressor. NF-kappaB signaling is known to be important for controlling cellular proliferation and protecting against apoptosis. In this report, merlin was demonstrated to be effective in suppressing the NF-kappaB signaling pathway in NIH3T3 and C6 cells. In addition, merlin blocked the tumor necrosis factor-alpha (TNF-alpha)-induced NF-kappaB-DNA binding mediated via the inhibition of degradation of IkappaBalpha and blocked the activation of NF-kappaB-dependent transcription. A reporter gene assay using deletion mutants of NF2 showed that the N-terminus (amino acids 1-130) of merlin may be important for its inhibition of NF-kappaB activation. These results show that merlin acts as a negative regulator of the NF-kappaB signaling pathway. (C) 2002 Elsevier Science (USA). All rights reserved. | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.296, no.5, pp.1295 - 1302 | - |
dc.identifier.doi | 10.1016/S0006-291X(02)02077-6 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.scopusid | 2-s2.0-0035984336 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/59772 | - |
dc.identifier.wosid | 000177987600041 | - |
dc.language | 영어 | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Inhibition of NF-kappa B activation by merlin | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Biophysics | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Biophysics | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | neurofibromatosis type 2 (NF2) | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | TNF-alpha | - |
dc.subject.keywordAuthor | p65 | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR | - |
dc.subject.keywordPlus | GENE-PRODUCT | - |
dc.subject.keywordPlus | NEUROFIBROMATOSIS TYPE-2 | - |
dc.subject.keywordPlus | TRANSCRIPTIONAL ACTIVITY | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | EZRIN | - |
dc.subject.keywordPlus | RAS | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.