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김홍태

Kim, Hongtae
Cancer/DNA damage Lab.
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dc.citation.endPage 293 -
dc.citation.number 5 -
dc.citation.startPage 289 -
dc.citation.title The Korean Journal of Physiology & Pharmacology -
dc.citation.volume 7 -
dc.contributor.author Kwak N.-J. -
dc.contributor.author Kim, Hongtae -
dc.contributor.author Choi B.H. -
dc.contributor.author Kim Y.H. -
dc.contributor.author Rha H.K. -
dc.contributor.author Lee K.-H. -
dc.date.accessioned 2023-12-22T11:08:42Z -
dc.date.available 2023-12-22T11:08:42Z -
dc.date.created 2022-10-17 -
dc.date.issued 2003-10 -
dc.description.abstract Mutations in the NF2 tumor suppressor gene cause neurofibromatosis type 2, an autosomal dominant inherited syndrome predisposed to the multiple tumors of the nervous system. Merlin, the NF2 gene product was reported to block Ras-mediated cell transformation and represses Ras-induced expression of cyclin D1. However, the potential mechanism underlying the anti-Ras function of merlin on the cyclin D1 is still unclear. In this study, we investigated whether merlin decreases Ha-ras-induced accumulation of cyclin D1 at the transcriptional level, and demonstrated that merlin suppressed Ras-induced cyclin D1 promoter activity mediated by the cyclic AMP-responsive element (CRE) in SK-N-BE(2)C neuroblastoma cells. Furthermore, we found that merlin attenuated active Ras and forskolin-induced CRE-driven promoter activity. These results suggest that the transcriptional repression of the cyclin D1 expression by merlin may contribute to the inhibition of Ras-induced cell proliferation. -
dc.identifier.bibliographicCitation The Korean Journal of Physiology & Pharmacology, v.7, no.5, pp.289 - 293 -
dc.identifier.issn 1226-4512 -
dc.identifier.scopusid 2-s2.0-0345865026 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/59770 -
dc.language 영어 -
dc.publisher 대한약리학회 -
dc.title Merlin represses ras-induced Cyclin D1 transcription through the cyclic AMP-responsive element -
dc.type Article -
dc.description.isOpenAccess FALSE -
dc.description.journalRegisteredClass scopus -
dc.description.journalRegisteredClass kci -
dc.description.journalRegisteredClass kci_candi -

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