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DC Field | Value | Language |
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dc.citation.endPage | 98 | - |
dc.citation.startPage | 88 | - |
dc.citation.title | MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | - |
dc.citation.volume | 809 | - |
dc.contributor.author | Lee, Nam Soo | - |
dc.contributor.author | Kim, Soomi | - |
dc.contributor.author | Jung, Yong Woo | - |
dc.contributor.author | Kim, Hongtae | - |
dc.date.accessioned | 2023-12-21T20:42:29Z | - |
dc.date.available | 2023-12-21T20:42:29Z | - |
dc.date.created | 2022-10-17 | - |
dc.date.issued | 2018-05 | - |
dc.description.abstract | To prevent genomic instability disorders, cells have developed a DNA damage response. The response involves various proteins that sense damaged DNA, transduce damage signals, and effect DNA repair. In addition, ubiquitin modifications modulate the signaling pathway depending on cellular context. Among various types of DNA damage, double-stranded breaks are highly toxic to genomic integrity. Homologous recombination (HR) repair is an essential mechanism that fixes DNA damage because of its high level of accuracy. Although factors in the repair pathway are well established, pinpointing the exact mechanisms of repair and devising therapeutic applications requires more studies. Moreover, essential functions of ubiquitin modification in the DNA damage signaling pathway have emerged. In this review, to explore the eukaryotic DNA damage response, we will mention the functions of main factors in the HR repair pathway and ubiquitin modification. | - |
dc.identifier.bibliographicCitation | MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, v.809, pp.88 - 98 | - |
dc.identifier.doi | 10.1016/j.mrfmmm.2017.04.003 | - |
dc.identifier.issn | 0027-5107 | - |
dc.identifier.scopusid | 2-s2.0-85019882487 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/59769 | - |
dc.identifier.wosid | 000432598800012 | - |
dc.language | 영어 | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Eukaryotic DNA damage responses: Homologous recombination factors and ubiquitin modification | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology | - |
dc.type.docType | Review | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | DNA damage response | - |
dc.subject.keywordAuthor | Homologous recombination repair pathway | - |
dc.subject.keywordAuthor | Ubiquitin modification | - |
dc.subject.keywordPlus | DOUBLE-STRAND BREAKS | - |
dc.subject.keywordPlus | TRAF-INTERACTING PROTEIN | - |
dc.subject.keywordPlus | MAINTAINS GENOMIC STABILITY | - |
dc.subject.keywordPlus | DEPENDENT SIGNALING CASCADE | - |
dc.subject.keywordPlus | CANCER SUSCEPTIBILITY GENE | - |
dc.subject.keywordPlus | REPAIR PATHWAY CHOICE | - |
dc.subject.keywordPlus | END RESECTION | - |
dc.subject.keywordPlus | BINDING PROTEIN | - |
dc.subject.keywordPlus | MRN COMPLEX | - |
dc.subject.keywordPlus | E3 LIGASE | - |
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