There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.number | 11 | - |
dc.citation.startPage | 1832 | - |
dc.citation.title | CELLS | - |
dc.citation.volume | 11 | - |
dc.contributor.author | Ryu, Eunjin | - |
dc.contributor.author | Ha, Na Young | - |
dc.contributor.author | Jung, Woojae | - |
dc.contributor.author | Yoo, Juyeong | - |
dc.contributor.author | Myung, Kyungjae | - |
dc.contributor.author | Kang, Sukhyun | - |
dc.date.accessioned | 2023-12-21T14:08:20Z | - |
dc.date.available | 2023-12-21T14:08:20Z | - |
dc.date.created | 2022-06-28 | - |
dc.date.issued | 2022-06 | - |
dc.description.abstract | Proliferating cell nuclear antigen (PCNA) is a DNA clamp that functions in key roles for DNA replication and repair. After the completion of DNA synthesis, PCNA should be unloaded from DNA in a timely way. The ATAD5-RFC-Like Complex (ATAD5-RLC) unloads PCNA from DNA. However, the mechanism of the PCNA-unloading process remains unclear. In this study, we determined the minimal PCNA-unloading domain (ULD) of ATAD5. We identified several motifs in the ATAD5 ULD that are essential in the PCNA-unloading process. The C-terminus of ULD is required for the stable association of RFC2-5 for active RLC formation. The N-terminus of ULD participates in the opening of the PCNA ring. ATAD5-RLC was more robustly bound to open-liable PCNA compared to the wild type. These results suggest that distinct motifs of the ATAD5 ULD participate in each step of the PCNA-unloading process. | - |
dc.identifier.bibliographicCitation | CELLS, v.11, no.11, pp.1832 | - |
dc.identifier.doi | 10.3390/cells11111832 | - |
dc.identifier.issn | 2073-4409 | - |
dc.identifier.scopusid | 2-s2.0-85131162550 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/59329 | - |
dc.identifier.wosid | 000808804700001 | - |
dc.language | 영어 | - |
dc.publisher | MDPI | - |
dc.title | Distinct Motifs in ATAD5 C-Terminal Domain Modulate PCNA Unloading Process | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | ATAD5 | - |
dc.subject.keywordAuthor | PCNA | - |
dc.subject.keywordAuthor | PCNA unloading | - |
dc.subject.keywordAuthor | RFC-like complex | - |
dc.subject.keywordAuthor | RLC | - |
dc.subject.keywordAuthor | SUMOylation | - |
dc.subject.keywordAuthor | RFC | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | CLAMP | - |
dc.subject.keywordPlus | LEVEL | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.