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DC Field | Value | Language |
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dc.citation.endPage | 2194 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 2182 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF CANCER | - |
dc.citation.volume | 151 | - |
dc.contributor.author | Yoon, Meesun | - |
dc.contributor.author | Lee, Hyo Kyung | - |
dc.contributor.author | Park, Eun Young | - |
dc.contributor.author | Kim, Jin Hee | - |
dc.contributor.author | Lee, Jong Hoon | - |
dc.contributor.author | Kim, Young Seok | - |
dc.contributor.author | Kim, Hak Jae | - |
dc.contributor.author | Kim, Hunjung | - |
dc.contributor.author | Yoo, Chong Woo | - |
dc.contributor.author | Lee, Sun | - |
dc.contributor.author | Hong, Eun Kyung | - |
dc.contributor.author | Kim, Tae Hyun | - |
dc.contributor.author | Kim, Tae-Sung | - |
dc.contributor.author | Seo, Sang-soo | - |
dc.contributor.author | Kang, Sokbom | - |
dc.contributor.author | Chang, Suk-Joon | - |
dc.contributor.author | Shin, Hye Jin | - |
dc.contributor.author | Uong, Tung Nguyen Thanh | - |
dc.contributor.author | Lee, Semin | - |
dc.contributor.author | Kim, Joo-Young | - |
dc.date.accessioned | 2023-12-21T13:16:47Z | - |
dc.date.available | 2023-12-21T13:16:47Z | - |
dc.date.created | 2022-07-28 | - |
dc.date.issued | 2022-12 | - |
dc.description.abstract | We conducted a prospective phase II study on whether extended-field irradiation (EFI) confers survival benefits depending on hypoxic markers in locally advanced uterine cervical cancer (LAUCC). RNA-seq was performed to identify immune and hypoxic gene signatures. A total of 288 patients were randomized to either EFI or pelvic radiotherapy (PRT). All patients completed chemoradiotherapy. Overall, significantly higher 5-year para-aortic recurrence free survival (PARFS) rate occurred in EFI (97.6%) than in PRT group (87.2%), with marginal tendency to improve disease-free survival (DFS; 78% vs 70%, P =.066). Subgroup analyses were performed based on carbonic anhydrase 9 (CA9)-only positive, CA9/hypoxia-inducible factor (HIF) double positive and CA9 negative. In the CA9-only positive, EFI successfully increased 5-year PARFS (100% vs 76.4%, P =.010), resulting in significantly improved long-term DFS (85.7% vs 54.7%, P =.023) compared to the PRT, while there was no such benefit of EFI in the CA9/HIFs double positive. RNA-seq analysis identified distinct immune(high) subgroup with negative correlation with hypoxia gene signatures (R = -.37, P <.01), which showed a higher 5-year DFS than the immune(low) (P =.032). Hypoxia-related genes were upregulated in the CA9/HIFs double positive compared to CA9 negative (P <.05). Only 17.4% of patients in CA9-negative group showed immune(low) signatures, while 40.0% of patients in the double-positive group exhibited immune(low) signatures. In conclusion, EFI improved PARFS significantly in all patients, but therapeutic efficacy of EFI in terms of improved DFS was solely observed in CA9-only positive LAUCC, and not in CA9/HIFs double-positive subgroup. RNA-seq analysis suggested that hypoxia-induced immunosuppression may be related to treatment resistance in LAUCC. | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CANCER, v.151, no.12, pp.2182 - 2194 | - |
dc.identifier.doi | 10.1002/ijc.34190 | - |
dc.identifier.issn | 0020-7136 | - |
dc.identifier.scopusid | 2-s2.0-85133711144 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/59044 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/ijc.34190 | - |
dc.identifier.wosid | 000822816800001 | - |
dc.language | 영어 | - |
dc.publisher | WILEY | - |
dc.title | Randomized multicenter phase II trial of prophylactic irradiation of para-aortic lymph nodes in advanced cervical cancer according to tumor hypoxia: Korean Radiation Oncology Group (KROG 07-01) study | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalResearchArea | Oncology | - |
dc.type.docType | Article; Early Access | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | CA9 | - |
dc.subject.keywordAuthor | extended-field irradiation | - |
dc.subject.keywordAuthor | HIF-1 alpha | - |
dc.subject.keywordAuthor | HIF-2 alpha | - |
dc.subject.keywordAuthor | locally advanced cervical cancer | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CARBONIC-ANHYDRASE-9 | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | MARKER | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | METASTASES | - |
dc.subject.keywordPlus | IX | - |
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