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이세민
Lee, Semin

이세민

Department of Biomedical Engineering(바이오메디컬공학과)

  • Computational Biology Lab.
  • Website
Research Interests
Cancer genomics;single-cell omics;structural bioinformatics;machine learning;precision medicine;구조생명정보학;기계학습;정밀의학;암유전체학;단일세포오믹스
Lab Description
We analyze a large number of cancer genomes using multiple omics approaches to characterize various kinds of germline/somatic alterations in many different human cancer types. In order to understand somatic mosaicism, heterogeneity, and evolution in cancer, we also use single-cell genomics approaches.
Researcher ID Research Gate ORCiD Scopus Google Scholar
Previous
Establishment of a patient-specific avatar organoid model derived from EUS-guided fine-needle biopsy for timely clinical application in pancreatic ductal adenocarcinoma (with video) File

Kim, Hyemin , Jang, Jinho , Choi, Jin Ho , Song, Joo Hye , Lee, Su Hyun , Park, Jiho Park , Ryoo, Si Kyong , Lee, Eun Mi , Jeong, Hyoung-oh , Kim, Seunghoon , et al

Article Issue Date2024-07 View12
Impaired binding affinity of YTHDC1 with METTL3/METTL14 results in R-loop accumulation in myelodysplastic neoplasms with DDX41 mutation File File

Hwang, Won Chan , Park, Kibeom , Park, Silvia , Cheon, Na Young , Lee, Ja Yil , Hwang, Taejoo , Lee, Semin , Lee, Jong-Mi , Ju, Min Kyung , Lee, Joo Rak , et al

Article Issue Date2024-06 View59
Comprehensive multiomics analysis reveals distinct differences between pediatric choroid plexus papilloma and carcinoma File File

Choi, Yeonsong , Choi, Seung Ah , Koh, Eun Jung , Yun, Ilsun , Park, Suhyun , Jeon, Sungwon , Kim, Yeonkyung , Park, Sangbeen , Woo, Donggeon , Phi, Ji Hoon , et al

Article Issue Date2024-06 View15
Korea4K: whole genome sequences of 4,157 Koreans with 107 phenotypes derived from extensive health check-ups File

Jeon, Sungwon , Choi, Hansol , Jeon, Yeonsu , Choi, Whan-Hyuk , Choi, Hyunjoo , An, Kyungwhan , Ryu, Hyojung , Bhak, Jihun , Lee, Hyeonjae , Kwon, Yoonsung , et al

Article Issue Date2024-04 View11
A role for mutations in AK9 and other genes affecting ependymal cells in idiopathic normal pressure hydrocephalus File File

Yang, Hong Wei , Lee, Semin , Berry, Bethany C. , Yang, Dejun , Zheng, Shaokuan , Carroll, Rona S , Park, Peter J , Johnson, Mark D.

Article Issue Date2023-12 View26
Single-cell RNA Sequencing Reveals Novel Cellular Factors for Response to Immunosuppressive Therapy in Aplastic Anemia File File

Jang, Jinho , Kim, Hongtae , Park, Sung-Soo , Kim, Miok , Min, Yong Ki , Jeong, Hyoung-oh , Kim, Seunghoon , Hwang, Taejoo , Choi, David Whee-Young , Kim, Hee-Je , et al

Article Issue Date2023-11 View62
Predicting preterm birth using machine learning techniques in oral microbiome File File

Hong, You Mi , Lee, Jaewoong , Cho, Dong Hyu , Jeon, Jung Hun , Kang, Jihoon , Kim, Min-Gul , Lee, Semin , Kim, Jin Kyu

Article Issue Date2023-11 View20
Genomic characteristics of triple negative apocrine carcinoma: a comparison to triple negative breast cancer File File

Kim, Ji-Yeon , Park, Sabin , Cho, Eun Yoon , Lee, Jeong Eon , Jung, Hae Hyun , Chae, Byung Joo , Kim, Seok Won , Nam, Seok Jin , Cho, Soo Youn , Park, Yeon Hee , et al

Article Issue Date2023-07 View22
Prediction of Treatment Response to Chemoimmunotherapy: Concerted Effort Needed File

Lim, Jun Hyeok , Lee, Semin , Ryu, Jeong-Seon

Article Issue Date2023-06 View14
Experimental systems for the analysis of mutational signatures: no 'one-size-fits-all' solution File File

Ivanov, Dmitri , Hwang, Taejoo , Sitko, Lukasz Karol , Lee, Semin , Gartner, Anton

Article Issue Date2023-06 View27
A heterozygous mutation in UBE2H in a patient with developmental delay leads to an aberrant brain development in zebrafish File File

Shin, Unbeom , Choi, Yeonsong , Ko, Hwa Soo , Myung, Kyungjae , Lee, Semin , Cheon, Chong Kun , Lee, Yoonsung

Article Issue Date2023-05 View21
GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer metastasis File

Lee, Yu Jin , Shin, Kyeong Jin , Jang, Hyun-Jun , Ryu, Jin-Sun , Lee, Chae Young , Yoon, Jong Hyuk , Seo, Jeong Kon , Park, Sabin , Lee, Semin , Je, A Reum , et al

Article Issue Date2023-02 View26
RAMP: response-aware multi-task learning with contrastive regularization for cancer drug response prediction File

Lee, Kanggeun , Cho, Dongbin , Jang, Jinho , Choi, Kang , Jeong, Hyoung-oh , Seo, Jiwon , Jeong, Won-Ki , Lee, Semin

Article Issue Date2023-01 View21
Randomized multicenter phase II trial of prophylactic irradiation of para-aortic lymph nodes in advanced cervical cancer according to tumor hypoxia: Korean Radiation Oncology Group (KROG 07-01) study File

Yoon, Meesun , Lee, Hyo Kyung , Park, Eun Young , Kim, Jin Hee , Lee, Jong Hoon , Kim, Young Seok , Kim, Hak Jae , Kim, Hunjung , Yoo, Chong Woo , Lee, Sun , et al

Article Issue Date2022-12 View28
Cellular plasticity and immune microenvironment of malignant pleural effusion are associated with EGFR-TKI resistance in non-small-cell lung carcinoma File File

Jeong, Hyoung-oh , Lee, Hayoon , Kim, Hyemin , Jang, Jinho , Kim, Seunghoon , Hwang, Taejoo , Choi, David Whee-Young , Kim, Hong Sook , Lee, Naeun , Lee, Yoo Mi , et al

Article Issue Date2022-11 View26
PWWP2B promotes DNA end resection and homologous recombination File

Ju, Min Kyung , Lee, Joo Rak , Choi, Yeonsong , Park, Seon Young , Sul, Hee Jung , Chung, Hee Jin , An, Soyeong , Lee, Semin , Jung, Eungyoung , Kim, Bohyun , et al

Article Issue Date2022-07 View48
Somatic mosaicism reveals clonal distributions of neocortical development File

Breuss, Martin W. , Yang, Xiaoxu , Schlachetzki, Johannes C. M. , Antaki, Danny , Lana, Addison J. , Xu, Xin , Chung, Changuk , Chai, Guoliang , Stanley, Valentina , Song, Qiong , et al

Article Issue Date2022-04 View21
A functional genomic approach to actionable gene fusions for precision oncology File File

Li, Jun , Lu, Hengyu , Ng, Patrick Kwok-Shing , Pantazi, Angeliki , Ip, Carman Ka Man , Jeong, Kang Jin , Amador, Bianca , Tran, Richard , Tsang, Yiu Huen , Yang, Lixing , et al

Article Issue Date2022-02 View24
Comparison of 3-month cytogenetic and molecular assays for early assessment of long-term clinical impact after BCR-ABL1 tyrosine kinase inhibitor treatment in chronic myeloid leukemia File

Kee, Kyung-Mi , Kim, Soo-Hyun , Yang, Seon-Young , Shin, Jeong-U , Nam, Yoon-Won , Jang, Eun-Jung , Kim, Hongtae , Lee, Semin , Park, Sung Ho , Kim, Dong-Wook

Article Issue Date2022-01 View26
Sex-specific difference of in-hospital mortality from COVID-19 in South Korea File File

Her, Ae-Young , Bhak, Youngjune , Jun, Eun Jung , Yuan, Song Lin , Garg, Scot , Lee, Semin , Bhak, Jong , Shin, Eun-Seok

Article Issue Date2022-01 View35
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