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이세민
Lee, Semin

이세민

Department of Biomedical Engineering(바이오메디컬공학과)

  • Computational Biology Lab.
  • Website
Research Interests
Cancer genomics;single-cell omics;structural bioinformatics;machine learning;precision medicine;구조생명정보학;기계학습;정밀의학;암유전체학;단일세포오믹스
Lab Description
We analyze a large number of cancer genomes using multiple omics approaches to characterize various kinds of germline/somatic alterations in many different human cancer types. In order to understand somatic mosaicism, heterogeneity, and evolution in cancer, we also use single-cell genomics approaches.
Researcher ID Research Gate ORCiD Scopus Google Scholar
Previous
Identification of 17 novel epigenetic biomarkers associated with anxiety disorders using differential methylation analysis followed by machine learning-based validation File

Kwon, Yoonsung , Blazyte, Asta , Jeon, Yeonsu , Kim, Yeo Jin , An, Kyungwhan , Jeon, Sungwon , Ryu, Hyojung , Shin, Dong-Hyun , Ahn, Jihye , Um, Hyojin , et al

Article Issue Date2025-02 View12
Comprehensive whole-genome sequencing reveals origins of mutational signatures associated with aging, mismatch repair deficiency and temozolomide chemotherapy File

Hwang, Taejoo , Sitko, Lukasz Karol , Khoirunnisa, Ratih , Navarro-Aguad, Fernanda , Samuel, David M. , Park, Hajoong , Cheon, Banyoon , Mutsnaini, Luthfiyyah , Lee, Jaewoong , Otlu, Burcak , et al

Article Issue Date2024-12 View31
Establishment of a patient-specific avatar organoid model derived from EUS-guided fine-needle biopsy for timely clinical application in pancreatic ductal adenocarcinoma (with video) File

Kim, Hyemin , Jang, Jinho , Choi, Jin Ho , Song, Joo Hye , Lee, Su Hyun , Park, Jiho Park , Ryoo, Si Kyong , Lee, Eun Mi , Jeong, Hyoung-oh , Kim, Seunghoon , et al

Article Issue Date2024-07 View34
Comprehensive multiomics analysis reveals distinct differences between pediatric choroid plexus papilloma and carcinoma File File

Choi, Yeonsong , Choi, Seung Ah , Koh, Eun Jung , Yun, Ilsun , Park, Suhyun , Jeon, Sungwon , Kim, Yeonkyung , Park, Sangbeen , Woo, Donggeon , Phi, Ji Hoon , et al

Article Issue Date2024-06 View80
Impaired binding affinity of YTHDC1 with METTL3/METTL14 results in R-loop accumulation in myelodysplastic neoplasms with DDX41 mutation File File

Hwang, Won Chan , Park, Kibeom , Park, Silvia , Cheon, Na Young , Lee, Ja Yil , Hwang, Taejoo , Lee, Semin , Lee, Jong-Mi , Ju, Min Kyung , Lee, Joo Rak , et al

Article Issue Date2024-06 View115
Mapping recurrent mosaic copy number variation in human neurons File

Sun, Chen , Kathuria, Kunal , Emery, Sarah B. , Kim, ByungJun , Burbulis, Ian E. , Shin, Joo Heon , Weinberger, Daniel R. , Moran, John V. , Kidd, Jeffrey M. , Mills, Ryan E. , et al

Article Issue Date2024-05 View28
Single-cell transcriptome analysis reveals subtype-specific clonal evolution and microenvironmental changes in liver metastasis of pancreatic adenocarcinoma and their clinical implications File

Park, Joo Kyung , Jeong, Hyoung-oh , Kim, Hyemin , Choi, Jin Ho , Lee, Eun Mi , Kim, Seunghoon , Jang, Jinho , Choi, David Whee-Young , Lee, Se-Hoon , Kim, Kyoung Mee , et al

Article Issue Date2024-05 View21
Korea4K: whole genome sequences of 4,157 Koreans with 107 phenotypes derived from extensive health check-ups File

Jeon, Sungwon , Choi, Hansol , Jeon, Yeonsu , Choi, Whan-Hyuk , Choi, Hyunjoo , An, Kyungwhan , Ryu, Hyojung , Bhak, Jihun , Lee, Hyeonjae , Kwon, Yoonsung , et al

Article Issue Date2024-04 View78
A role for mutations in AK9 and other genes affecting ependymal cells in idiopathic normal pressure hydrocephalus File File

Yang, Hong Wei , Lee, Semin , Berry, Bethany C. , Yang, Dejun , Zheng, Shaokuan , Carroll, Rona S , Park, Peter J , Johnson, Mark D.

Article Issue Date2023-12 View43
Predicting preterm birth using machine learning techniques in oral microbiome File File

Hong, You Mi , Lee, Jaewoong , Cho, Dong Hyu , Jeon, Jung Hun , Kang, Jihoon , Kim, Min-Gul , Lee, Semin , Kim, Jin Kyu

Article Issue Date2023-11 View35
Single-cell RNA Sequencing Reveals Novel Cellular Factors for Response to Immunosuppressive Therapy in Aplastic Anemia File File

Jang, Jinho , Kim, Hongtae , Park, Sung-Soo , Kim, Miok , Min, Yong Ki , Jeong, Hyoung-oh , Kim, Seunghoon , Hwang, Taejoo , Choi, David Whee-Young , Kim, Hee-Je , et al

Article Issue Date2023-11 View90
Genomic characteristics of triple negative apocrine carcinoma: a comparison to triple negative breast cancer File File

Kim, Ji-Yeon , Park, Sabin , Cho, Eun Yoon , Lee, Jeong Eon , Jung, Hae Hyun , Chae, Byung Joo , Kim, Seok Won , Nam, Seok Jin , Cho, Soo Youn , Park, Yeon Hee , et al

Article Issue Date2023-07 View46
Experimental systems for the analysis of mutational signatures: no 'one-size-fits-all' solution File File

Ivanov, Dmitri , Hwang, Taejoo , Sitko, Lukasz Karol , Lee, Semin , Gartner, Anton

Article Issue Date2023-06 View58
Control-independent mosaic single nucleotide variant detection with DeepMosaic File

Yang, Xiaoxu , Xu, Xin , Breuss, Martin W. , Antaki, Danny , Ball, Laurel L. V. , Chung, Changuk , Shen, Jiawei , Li, Chen , George, Renee D. , Wang, Yifan , et al

Article Issue Date2023-06 View18
Prediction of Treatment Response to Chemoimmunotherapy: Concerted Effort Needed File

Lim, Jun Hyeok , Lee, Semin , Ryu, Jeong-Seon

Article Issue Date2023-06 View44
A heterozygous mutation in UBE2H in a patient with developmental delay leads to an aberrant brain development in zebrafish File File

Shin, Unbeom , Choi, Yeonsong , Ko, Hwa Soo , Myung, Kyungjae , Lee, Semin , Cheon, Chong Kun , Lee, Yoonsung

Article Issue Date2023-05 View54
GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer metastasis File

Lee, Yu Jin , Shin, Kyeong Jin , Jang, Hyun-Jun , Ryu, Jin-Sun , Lee, Chae Young , Yoon, Jong Hyuk , Seo, Jeong Kon , Park, Sabin , Lee, Semin , Je, A Reum , et al

Article Issue Date2023-02 View60
Comprehensive multi-omic profiling of somatic mutations in malformations of cortical development File

Chung, Changuk , Yang, Xiaoxu , Bae, Taejeong , Vong, Keng Ioi , Mittal, Swapnil H. , Donkels, Catharina , Westley Phillips, H. , Li, Zhen , Marsh, Ashley P. L. , Breuss, Martin , et al

Article Issue Date2023-02 View30
RAMP: response-aware multi-task learning with contrastive regularization for cancer drug response prediction File

Lee, Kanggeun , Cho, Dongbin , Jang, Jinho , Choi, Kang , Jeong, Hyoung-oh , Seo, Jiwon , Jeong, Won-Ki , Lee, Semin

Article Issue Date2023-01 View62
Randomized multicenter phase II trial of prophylactic irradiation of para-aortic lymph nodes in advanced cervical cancer according to tumor hypoxia: Korean Radiation Oncology Group (KROG 07-01) study File

Yoon, Meesun , Lee, Hyo Kyung , Park, Eun Young , Kim, Jin Hee , Lee, Jong Hoon , Kim, Young Seok , Kim, Hak Jae , Kim, Hunjung , Yoo, Chong Woo , Lee, Sun , et al

Article Issue Date2022-12 View52
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