Methanol steam reforming (MSR) in packed-bed reactors (PBRs) with membrane filters has emerged as promising hydrogen (H-2) production system to overcome limitations of conventional membrane reactor (MR), which has H-2 permeable membrane inside. In this study, techno-economic analysis is conducted based on results of process simulation using Aspen HYSYS (R) to assess technical and economic feasibility of MSR in systems of different number of PBRs and membrane filters and key economic parameters are presented. Also, effects of techno-economic parameters of reaction temperature, H-2 permeance, and the number of PBRs and membrane filters on a unit H-2 production cost are investigated, individually and comprehensively, in the ranges from 448 to 513 K, from 5 x 10(-6) to 5 x 10(-5) mol m(-2) s(-1) Pa-1, and one to four PBRs with zero to three membrane filters. Based on techno-economic analysis results, regression function for the unit H-2 production cost is achieved and optimization of operating conditions using GAMS (c) is conducted showing the minimum unit H-2 production cost of 7.03 $ kgH(2)(-1) and optimized conditions of 513 K, 5 x 10(-5) mol m(-2) s(-1) Pa-1, and two PBRs with one membrane filter. In addition, to investigate environmental feasibility, carbon footprint analysis is performed with comparing CO2 emissions according to techno-economic parameters. (C)& nbsp;2021 Elsevier Ltd. All rights reserved.