There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.number | 7 | - |
dc.citation.startPage | e53492 | - |
dc.citation.title | EMBO REPORTS | - |
dc.citation.volume | 23 | - |
dc.contributor.author | Ju, Min Kyung | - |
dc.contributor.author | Lee, Joo Rak | - |
dc.contributor.author | Choi, Yeonsong | - |
dc.contributor.author | Park, Seon Young | - |
dc.contributor.author | Sul, Hee Jung | - |
dc.contributor.author | Chung, Hee Jin | - |
dc.contributor.author | An, Soyeong | - |
dc.contributor.author | Lee, Semin | - |
dc.contributor.author | Jung, Eungyoung | - |
dc.contributor.author | Kim, Bohyun | - |
dc.contributor.author | Choi, Bo Youn | - |
dc.contributor.author | Kim, Bum Jun | - |
dc.contributor.author | Kim, Heong Su | - |
dc.contributor.author | Lim, Hyun | - |
dc.contributor.author | Kang, Ho Suk | - |
dc.contributor.author | Soh, Jae Seung | - |
dc.contributor.author | Myung, Kyungjae | - |
dc.contributor.author | Kim, Kab Choong | - |
dc.contributor.author | Cho, Ji Woong | - |
dc.contributor.author | Seo, Jinwon | - |
dc.contributor.author | Kim, Tae Moon | - |
dc.contributor.author | Lee, Ja Yil | - |
dc.contributor.author | Kim, Yonghwan | - |
dc.contributor.author | Kim, Hongtae | - |
dc.contributor.author | Zang, Dae Young | - |
dc.date.accessioned | 2023-12-21T14:07:04Z | - |
dc.date.available | 2023-12-21T14:07:04Z | - |
dc.date.created | 2022-05-18 | - |
dc.date.issued | 2022-07 | - |
dc.description.abstract | Genome instability is one of the leading causes of gastric cancers. However, the mutational landscape of driver genes in gastric cancer is poorly understood. Here, we investigate somatic mutations in 25 Korean gastric adenocarcinoma patients using whole-exome sequencing and show that PWWP2B is one of the most frequently mutated genes. PWWP2B mutation correlates with lower cancer patient survival. We find that PWWP2B has a role in DNA double-strand break repair. As a nuclear protein, PWWP2B moves to sites of DNA damage through its interaction with UHRF1. Depletion of PWWP2B enhances cellular sensitivity to ionizing radiation (IR) and impairs IR-induced foci formation of RAD51. PWWP2B interacts with MRE11 and participates in homologous recombination via promoting DNA end-resection. Taken together, our data show that PWWP2B facilitates the recruitment of DNA repair machinery to sites of DNA damage and promotes HR-mediated DNA double-strand break repair. Impaired PWWP2B function might thus cause genome instability and promote gastric cancer development. | - |
dc.identifier.bibliographicCitation | EMBO REPORTS, v.23, no.7, pp.e53492 | - |
dc.identifier.doi | 10.15252/embr.202153492 | - |
dc.identifier.issn | 1469-221X | - |
dc.identifier.scopusid | 2-s2.0-85130238348 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/58561 | - |
dc.identifier.url | https://www.embopress.org/doi/full/10.15252/embr.202153492 | - |
dc.identifier.wosid | 000796859100001 | - |
dc.language | 영어 | - |
dc.publisher | WILEY | - |
dc.title | PWWP2B promotes DNA end resection and homologous recombination | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology;Cell Biology | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology;Cell Biology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | end resection | - |
dc.subject.keywordAuthor | gastric cancer | - |
dc.subject.keywordAuthor | homologous recombination | - |
dc.subject.keywordAuthor | PWWP2B | - |
dc.subject.keywordAuthor | UHRF1 | - |
dc.subject.keywordPlus | MICROSATELLITE INSTABILITY | - |
dc.subject.keywordPlus | GASTRIC-CANCER | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | REPAIR | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | DOMAIN | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | ATM | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.