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Cha, Chaenyung
Integrative Biomaterials Engineering
Research Interests
  • Biopolymer, nanocomposites, microfabrication, tissue engineering, drug delivery

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25th Anniversary Article: Rational Design and Applications of Hydrogels in Regenerative Medicine

Cited 43 times inthomson ciCited 12 times inthomson ci
Title
25th Anniversary Article: Rational Design and Applications of Hydrogels in Regenerative Medicine
Author
Annabi, NasimTamayol, AliUquillas, Jorge AlfredoAkbari, MohsenBertassoni, Luiz E.Cha, ChaenyungCamci-Unal, GuldenDokmeci, Mehmet R.Peppas, Nicholas A.Khademhosseini, Ali
Keywords
Biomedical applications; Micro-engineering; Minimally invasive surgery; Native extracellular matrix; Physical characteristics; Physio-chemical properties; Regenerative medicine; Smart biomaterials
Issue Date
2014-01
Publisher
WILEY-V C H VERLAG GMBH
Citation
ADVANCED MATERIALS, v.26, no.1, pp.85 - 124
Abstract
Hydrogels are hydrophilic polymer-based materials with high water content and physical characteristics that resemble the native extracellular matrix. Because of their remarkable properties, hydrogel systems are used for a wide range of biomedical applications, such as three-dimensional (3D) matrices for tissue engineering, drug-delivery vehicles, composite biomaterials, and as injectable fillers in minimally invasive surgeries. In addition, the rational design of hydrogels with controlled physical and biological properties can be used to modulate cellular functionality and tissue morphogenesis. Here, the development of advanced hydrogels with tunable physiochemical properties is highlighted, with particular emphasis on elastomeric, light-sensitive, composite, and shape-memory hydrogels. Emerging technologies developed over the past decade to control hydrogel architecture are also discussed and a number of potential applications and challenges in the utilization of hydrogels in regenerative medicine are reviewed. It is anticipated that the continued development of sophisticated hydrogels will result in clinical applications that will improve patient care and quality of life. Recent advances in the design of hydrogels with tunable physiochemical and biological properties and their potential applications in regenerative medicine are discussed, along with emerging technologies developed over the past decade to control the micro- and nanoscale architectures of three-dimensional hydrogels for clinical use.
URI
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DOI
10.1002/adma.201303233
ISSN
0935-9648
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