Full metadata record
DC Field | Value | Language |
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dc.citation.number | 6 | - |
dc.citation.startPage | eabm2382 | - |
dc.citation.title | SCIENCE ADVANCES | - |
dc.citation.volume | 8 | - |
dc.contributor.author | Li, Jun | - |
dc.contributor.author | Lu, Hengyu | - |
dc.contributor.author | Ng, Patrick Kwok-Shing | - |
dc.contributor.author | Pantazi, Angeliki | - |
dc.contributor.author | Ip, Carman Ka Man | - |
dc.contributor.author | Jeong, Kang Jin | - |
dc.contributor.author | Amador, Bianca | - |
dc.contributor.author | Tran, Richard | - |
dc.contributor.author | Tsang, Yiu Huen | - |
dc.contributor.author | Yang, Lixing | - |
dc.contributor.author | Song, Xingzhi | - |
dc.contributor.author | Dogruluk, Turgut | - |
dc.contributor.author | Ren, Xiaojia | - |
dc.contributor.author | Hadjipanayis, Angela | - |
dc.contributor.author | Bristow, Christopher A. | - |
dc.contributor.author | Lee, Semin | - |
dc.contributor.author | Kucherlapati, Melanie | - |
dc.contributor.author | Parfenov, Michael | - |
dc.contributor.author | Tang, Jiabin | - |
dc.contributor.author | Seth, Sahil | - |
dc.contributor.author | Mahadeshwar, Harshad S. | - |
dc.contributor.author | Mojumdar, Kamalika | - |
dc.contributor.author | Zeng, Dong | - |
dc.contributor.author | Zhang, Jianhua | - |
dc.contributor.author | Protopopov, Alexei | - |
dc.contributor.author | Seidman, Jonathan G. | - |
dc.contributor.author | Creighton, Chad J. | - |
dc.contributor.author | Lu, Yiling | - |
dc.contributor.author | Sahni, Nidhi | - |
dc.contributor.author | Shaw, Kenna R. | - |
dc.contributor.author | Meric-Bernstam, Funda | - |
dc.contributor.author | Futreal, Andrew | - |
dc.contributor.author | Chin, Lynda | - |
dc.contributor.author | Scott, Kenneth L. | - |
dc.contributor.author | Kucherlapati, Raju | - |
dc.contributor.author | Mills, Gordon B. | - |
dc.contributor.author | Liang, Han | - |
dc.date.accessioned | 2023-12-21T14:37:36Z | - |
dc.date.available | 2023-12-21T14:37:36Z | - |
dc.date.created | 2022-05-16 | - |
dc.date.issued | 2022-02 | - |
dc.description.abstract | Fusion genes represent a class of attractive therapeutic targets. Thousands of fusion genes have been identified in patients with cancer, but the functional consequences and therapeutic implications of most of these remain largely unknown. Here, we develop a functional genomic approach that consists of efficient fusion reconstruction and sensitive cell viability and drug response assays. Applying this approach, we characterize similar to 100 fusion genes detected in patient samples of The Cancer Genome Atlas, revealing a notable fraction of low-frequency fusions with activating effects on tumor growth. Focusing on those in the RTK-RAS pathway, we identify a number of activating fusions that can markedly affect sensitivity to relevant drugs. Last, we propose an integrated, level-of-evidence classification system to prioritize gene fusions systematically. Our study reiterates the urgent clinical need to incorporate similar functional genomic approaches to characterize gene fusions, thereby maximizing the utility of gene fusions for precision oncology. | - |
dc.identifier.bibliographicCitation | SCIENCE ADVANCES, v.8, no.6, pp.eabm2382 | - |
dc.identifier.doi | 10.1126/sciadv.abm2382 | - |
dc.identifier.issn | 2375-2548 | - |
dc.identifier.scopusid | 2-s2.0-85124261235 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/58449 | - |
dc.identifier.wosid | 000753670300009 | - |
dc.language | 영어 | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.title | A functional genomic approach to actionable gene fusions for precision oncology | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | MELANOMA | - |
dc.subject.keywordPlus | DRIVERS | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | FGFR | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | SUBTYPE | - |
dc.subject.keywordPlus | EXOME | - |
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