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DC Field | Value | Language |
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dc.citation.endPage | 696 | - |
dc.citation.startPage | 689 | - |
dc.citation.title | NATURE | - |
dc.citation.volume | 604 | - |
dc.contributor.author | Breuss, Martin W. | - |
dc.contributor.author | Yang, Xiaoxu | - |
dc.contributor.author | Schlachetzki, Johannes C. M. | - |
dc.contributor.author | Antaki, Danny | - |
dc.contributor.author | Lana, Addison J. | - |
dc.contributor.author | Xu, Xin | - |
dc.contributor.author | Chung, Changuk | - |
dc.contributor.author | Chai, Guoliang | - |
dc.contributor.author | Stanley, Valentina | - |
dc.contributor.author | Song, Qiong | - |
dc.contributor.author | Newmeyer, Traci F. | - |
dc.contributor.author | An Nguyen | - |
dc.contributor.author | O'Brien, Sydney | - |
dc.contributor.author | Hoeksema, Marten A. | - |
dc.contributor.author | Cao, Beibei | - |
dc.contributor.author | Nott, Alexi | - |
dc.contributor.author | McEvoy-Venneri, Jennifer | - |
dc.contributor.author | Pasillas, Martina P. | - |
dc.contributor.author | Barton, Scott T. | - |
dc.contributor.author | Copeland, Brett R. | - |
dc.contributor.author | Nahas, Shareef | - |
dc.contributor.author | Van der Kraan, Lucitia | - |
dc.contributor.author | Ding, Yan | - |
dc.contributor.author | Glass, Christopher K. | - |
dc.contributor.author | Gleeson, Joseph G. | - |
dc.contributor.author | Lee, Semin | - |
dc.contributor.author | NIMH Brain Somatic Mosaicism Network | - |
dc.date.accessioned | 2023-12-21T14:15:39Z | - |
dc.date.available | 2023-12-21T14:15:39Z | - |
dc.date.created | 2022-05-16 | - |
dc.date.issued | 2022-04 | - |
dc.description.abstract | The structure of the human neocortex underlies species-specifictraits and reflects intricate developmental programs. Here we sought to reconstruct processes that occur during early development by sampling adult human tissues. We analysed neocortical clones in a post-mortem human brain through a comprehensive assessment of brain somatic mosaicism, acting as neutral lineage recorders(1,2). We combined the sampling of 25 distinct anatomic locations with deep whole-genome sequencing in a neurotypical deceased individual and confirmed results with 5 samples collected from each of three additional donors. We identified 259 bona fide mosaic variants from the index case, then deconvolved distinct geographical, cell-type and Glade organizations across the brain and other organs. We found that clones derived after the accumulation of 90-200 progenitors in the cerebral cortex tended to respect the midline axis, well before the anterior-posterior or ventral-dorsal axes, representing a secondary hierarchy following the overall patterning of forebrain and hindbrain domains. Clones across neocortically derived cells were consistent with a dual origin from both dorsal and ventral cellular populations, similar to rodents, whereas the microglia lineage appeared distinct from other resident brain cells. Our data provide a comprehensive analysis of brain somatic mosaicism across the neocortex and demonstrate cellular origins and progenitor distribution patterns within the human brain. | - |
dc.identifier.bibliographicCitation | NATURE, v.604, pp.689 - 696 | - |
dc.identifier.doi | 10.1038/s41586-022-04602-7 | - |
dc.identifier.issn | 0028-0836 | - |
dc.identifier.scopusid | 2-s2.0-85129779690 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/58430 | - |
dc.identifier.wosid | 000784115900004 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PORTFOLIO | - |
dc.title | Somatic mosaicism reveals clonal distributions of neocortical development | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.type.docType | Article; Early Access | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | LINEAGE | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | DISPERSION | - |
dc.subject.keywordPlus | ASYMMETRY | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | GENOME | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | EMBRYONIC-DEVELOPMENT | - |
dc.subject.keywordPlus | NEURONS | - |
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