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Myung, Kyungjae
Center for Genomic Integrity
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dc.citation.endPage 4020 -
dc.citation.number 21 -
dc.citation.startPage 4005 -
dc.citation.title CANCER MEDICINE -
dc.citation.volume 11 -
dc.contributor.author Park, Kibeom -
dc.contributor.author Yoo, Hee-Seop -
dc.contributor.author Oh, Chang-Kyu -
dc.contributor.author Lee, Joo Rak -
dc.contributor.author Chung, Hee Jin -
dc.contributor.author Kim, Ha-Neul -
dc.contributor.author Kim, Soo-Hyun -
dc.contributor.author Kee, Kyung-Mi -
dc.contributor.author Kim, Tong Yoon -
dc.contributor.author Kim, Myungshin -
dc.contributor.author Kim, Byung-Gyu -
dc.contributor.author Ra, Jae Sun -
dc.contributor.author Myung, Kyungjae -
dc.contributor.author Kim, Hongtae -
dc.contributor.author Han, Seung Hun -
dc.contributor.author Seo, Min-Duk -
dc.contributor.author Lee, Yoonsung -
dc.contributor.author Kim, Dong-Wook -
dc.date.accessioned 2023-12-21T13:36:42Z -
dc.date.available 2023-12-21T13:36:42Z -
dc.date.created 2022-04-15 -
dc.date.issued 2022-11 -
dc.description.abstract Cobll1 affects blast crisis (BC) progression and tyrosine kinase inhibitor (TKI) resistance in chronic myeloid leukemia (CML). PACSIN2, a novel Cobll1 binding protein, activates TKI-induced apoptosis in K562 cells, and this activation is suppressed by Cobll1 through the interaction between PACSIN2 and Cobll1. PACSIN2 also binds and inhibits SH3BP1 which activates the downstream Rac1 pathway and induces TKI resistance. PACSIN2 competitively interacts with Cobll1 or SH3BP1 with a higher affinity for Cobll1. Cobll1 preferentially binds to PACSIN2, releasing SH3BP1 to promote the SH3BP1/Rac1 pathway and suppress TKI-mediated apoptosis and eventually leading to TKI resistance. Similar interactions among Cobll1, PACSIN2, and SH3BP1 control hematopoiesis during vertebrate embryogenesis. Clinical analysis showed that most patients with CML have Cobll1 and SH3BP1 expression at the BC phase and BC patients with Cobll1 and SH3BP1 expression showed severe progression with a higher blast percentage than those without any Cobll1, PACSIN2, or SH3BP1 expression. Our study details the molecular mechanism of the Cobll1/PACSIN2/SH3BP1 pathway in regulating drug resistance and BC progression in CML. -
dc.identifier.bibliographicCitation CANCER MEDICINE, v.11, no.21, pp.4005 - 4020 -
dc.identifier.doi 10.1002/cam4.4727 -
dc.identifier.issn 2045-7634 -
dc.identifier.scopusid 2-s2.0-85127469685 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/58300 -
dc.identifier.url https://onlinelibrary.wiley.com/doi/10.1002/cam4.4727 -
dc.identifier.wosid 000774757700001 -
dc.language 영어 -
dc.publisher WILEY -
dc.title Reciprocal interactions among Cobll1, PACSIN2, and SH3BP1 regulate drug resistance in chronic myeloid leukemia -
dc.type Article -
dc.description.isOpenAccess FALSE -
dc.relation.journalWebOfScienceCategory Oncology -
dc.relation.journalResearchArea Oncology -
dc.type.docType Article; Early Access -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.subject.keywordAuthor blastic transformation -
dc.subject.keywordAuthor chronic myeloid leukemia -
dc.subject.keywordAuthor Cobll1 -
dc.subject.keywordAuthor PACSIN2 -
dc.subject.keywordAuthor SH3BP1 -
dc.subject.keywordPlus CHRONIC MYELOGENOUS LEUKEMIA -
dc.subject.keywordPlus IMATINIB RESISTANCE -
dc.subject.keywordPlus INHIBITOR -
dc.subject.keywordPlus MECHANISMS -
dc.subject.keywordPlus EXPRESSION -
dc.subject.keywordPlus MIGRATION -
dc.subject.keywordPlus CAVEOLAE -
dc.subject.keywordPlus MUTATION -
dc.subject.keywordPlus BIOLOGY -
dc.subject.keywordPlus FAMILY -

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