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Myung, Kyungjae
Center for Genomic Integrity
Research Interests
  • DNA Replication, DNA Repair, DNA Recombination, DNA Damage Response, cancer, aging

Reciprocal interactions among Cobll1, PACSIN2, and SH3BP1 regulate drug resistance in chronic myeloid leukemia

DC Field Value Language Park, Kibeom ko Yoo, Hee-Seop ko Oh, Chang-Kyu ko Lee, Joo Rak ko Chung, Hee Jin ko Kim, Ha-Neul ko Kim, Soo-Hyun ko Kee, Kyung-Mi ko Kim, Tong Yoon ko Kim, Myungshin ko Kim, Byung-Gyu ko Ra, Jae Sun ko Myung, Kyungjae ko Kim, Hongtae ko Han, Seung Hun ko Seo, Min-Duk ko Lee, Yoonsung ko Kim, Dong-Wook ko 2022-04-22T00:20:55Z - 2022-04-15 ko 2022-11 ko
dc.identifier.citation CANCER MEDICINE, v.11, no.21, pp.4005 - 4020 ko
dc.identifier.issn 2045-7634 ko
dc.identifier.uri -
dc.description.abstract Cobll1 affects blast crisis (BC) progression and tyrosine kinase inhibitor (TKI) resistance in chronic myeloid leukemia (CML). PACSIN2, a novel Cobll1 binding protein, activates TKI-induced apoptosis in K562 cells, and this activation is suppressed by Cobll1 through the interaction between PACSIN2 and Cobll1. PACSIN2 also binds and inhibits SH3BP1 which activates the downstream Rac1 pathway and induces TKI resistance. PACSIN2 competitively interacts with Cobll1 or SH3BP1 with a higher affinity for Cobll1. Cobll1 preferentially binds to PACSIN2, releasing SH3BP1 to promote the SH3BP1/Rac1 pathway and suppress TKI-mediated apoptosis and eventually leading to TKI resistance. Similar interactions among Cobll1, PACSIN2, and SH3BP1 control hematopoiesis during vertebrate embryogenesis. Clinical analysis showed that most patients with CML have Cobll1 and SH3BP1 expression at the BC phase and BC patients with Cobll1 and SH3BP1 expression showed severe progression with a higher blast percentage than those without any Cobll1, PACSIN2, or SH3BP1 expression. Our study details the molecular mechanism of the Cobll1/PACSIN2/SH3BP1 pathway in regulating drug resistance and BC progression in CML. ko
dc.language 영어 ko
dc.publisher WILEY ko
dc.title Reciprocal interactions among Cobll1, PACSIN2, and SH3BP1 regulate drug resistance in chronic myeloid leukemia ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-85127469685 ko
dc.identifier.wosid 000774757700001 ko
dc.type.rims ART ko
dc.identifier.doi 10.1002/cam4.4727 ko
dc.identifier.url ko
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