Two different 2D layered metal-organic frameworks (MOFs) have been prepared using a hexanuclear manganese metallamacrocycle and an octanuclear manganese metallamacrocycle as supramolecular building blocks via a simple change of the solvent used and/or addition of a templating agent. While the sheets in the 2D MOF [Mn(6)(pshz)(6)(bpea)(2)(dma)(2)](n), 2 (where, pshz(3-) is N-propionylsalicylhydrazidate, bpea is 1,2-bis(pyridyl)ethane, and dma is N,N-dimethylacetamide), built based on a hexanuclear metalladiazamacrocycle are in a staggered orientation, the sheets in the 2D MOF [Mn(8)(pshz)(8)(bpea)(2)(dma)(4)](n), 3, built based on an octanuclear metalladiazamacrocycle are in an eclipsed orientation. However, both MOFs have the same 3-connected 4.8(2) network topology.