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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 49 | - |
dc.citation.startPage | 42 | - |
dc.citation.title | CURRENT OPINION IN MICROBIOLOGY | - |
dc.citation.volume | 59 | - |
dc.contributor.author | Place, David E. | - |
dc.contributor.author | Lee, SangJoon | - |
dc.contributor.author | Kanneganti, Thirumala-Devi | - |
dc.date.accessioned | 2023-12-21T16:13:08Z | - |
dc.date.available | 2023-12-21T16:13:08Z | - |
dc.date.created | 2022-03-08 | - |
dc.date.issued | 2021-02 | - |
dc.description.abstract | The immune system has evolved multiple mechanisms to restrict microbial infections and regulate inflammatory responses. Without appropriate regulation, infection-induced inflammatory pathology can be deadly. The innate immune system recognizes the microbial molecules conserved in many pathogens and engages a rapid response by producing inflammatory mediators and activating programmed cell death pathways, including pyroptosis, apoptosis, and necroptosis. Activation of pattern recognition receptors, in combination with inflammatory cytokine-induced signaling through death domain-containing receptors, initiates a highly interconnected cell death process called PANoptosis (pyroptosis, apoptosis, necroptosis). Broadly speaking, PANoptosis is critical for restricting a wide range of pathogens (including bacteria, viruses, fungi, and parasites), which we describe in this review. We propose that re-examining the role of cell death and inflammatory cytokines through the lens of PANoptosis will advance our understanding of host-pathogen evolution and may reveal new treatment strategies for controlling a wide range of infectious diseases. | - |
dc.identifier.bibliographicCitation | CURRENT OPINION IN MICROBIOLOGY, v.59, pp.42 - 49 | - |
dc.identifier.doi | 10.1016/j.mib.2020.07.012 | - |
dc.identifier.issn | 1369-5274 | - |
dc.identifier.scopusid | 2-s2.0-85089496256 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/57780 | - |
dc.identifier.wosid | 000613986000007 | - |
dc.language | 영어 | - |
dc.publisher | CURRENT BIOLOGY LTD | - |
dc.title | PANoptosis in microbial infection | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.type.docType | Review | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | INFLAMMASOME ACTIVATION | - |
dc.subject.keywordPlus | CELL-DEATH | - |
dc.subject.keywordPlus | IL-1-BETA PRODUCTION | - |
dc.subject.keywordPlus | NLRP3 | - |
dc.subject.keywordPlus | CASPASE-8 | - |
dc.subject.keywordPlus | PATHOGEN | - |
dc.subject.keywordPlus | NLRC4 | - |
dc.subject.keywordPlus | AIM2 | - |
dc.subject.keywordPlus | RECRUITMENT | - |
dc.subject.keywordPlus | REGULATOR | - |
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