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이상준
Lee, SangJoon

이상준

Department of Biological Sciences(생명과학과)

  • Viral Immunology Lab.
Research Interests
Bacterial Infections;Immunity;Virology;Virus;Innate immunity;Cell death;Inflammasome;Inflammation;PANoptosis;세균감염;면역;바이러스학;염증조절복합체;염증;아포토시스
Lab Description
Innate immunity is the first line of defense against infectious disease. The resulting inflammation is the first response to infection and injury. Pathogen sensing and signaling in innate immune and barrier cells drive inflammation to combat infection. Excessive or chronic inflammation can contribute to the development and many diseases. Our laboratory seeks to gain fundamental insight into innate immune mechanisms to identify novel processes and new molecular targets. This will inform the development of therapeutic strategies.
Researcher ID Research Gate ORCiD Scopus Google Scholar
Previous
Integrated NLRP3, AIM2, NLRC4, Pyrin inflammasome activation and assembly drive PANoptosis File

Oh, Suhyeon , Lee, Jihye , Oh, Jueun , Yu, Gyoengju , Ryu, Haesun , Kim, Daesik , Lee, SangJoon

Article Issue Date2023-11 View11
Recent advances in ZBP1-derived PANoptosis against viral infections File File

Oh, SuHyeon , Lee, SangJoon

Article Issue Date2023-05 View11
Single cell analysis of PANoptosome cell death complexes through an expansion microscopy method File

Wang, Yaqiu , Pandian, Nagakannan , Han, Joo-Hui , Sundaram, Balamurugan , Lee, SangJoon , Karki, Rajendra , Guy, Clifford S. , Kanneganti, Thirumala-Devi

Article Issue Date2022-10 View12
Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation File File

Wang, Yaqiu , Karki, Rajendra , Mall, Raghvendra , Sharma, Bhesh Raj , Kalathur, Ravi C. , Lee, SangJoon , Kancharana, Balabhaskararao , So, Matthew , Combs, Katie L. , Kanneganti, Thirumala-Devi

Article Issue Date2022-10 View15
ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection File File

Karki, Rajendra , Lee, SangJoon , Mall, Raghvendra , Pandian, Nagakannan , Wang, Yaqiu , Sharma, Bhesh Raj , Malireddi, RK Subbarao , Yang, Dong , Trifkovic, Sanja , Steele, Jacob A. , et al

Article Issue Date2022-08 View25
Targeting MicroRNA-485-3p Blocks Alzheimer's Disease Progression File File

Koh, Han Seok , Lee, SangJoon , Lee, Hyo Jin , Min, Jae-Woong , Iwatsubo, Takeshi , Teunissen, Charlotte E. , Cho, Hyun-Jeong , Ryu, Jin-Hyeob

Article Issue Date2021-12 View10
Cutting Edge: Caspase-8 Is a Linchpin in Caspase-3 and Gasdermin D Activation to Control Cell Death, Cytokine Release, and Host Defense during Influenza A Virus Infection File

Wang, Yaqiu , Karki, Rajendra , Zheng, Min , Kancharana, Balabhaskararao , Lee, SangJoon , Kesavardhana, Sannula , Hansen, Baranda S. , Pruett-Miller, Shondra M. , Kanneganti, Thirumala-Devi

Article Issue Date2021-11 View5
Innate Immunity and Cell Death in Alzheimer's Disease File

Lee, SangJoon , Cho, Hyun-Jeong , Ryu, Jin-Hyeob

Article Issue Date2021-10 View2
ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis File

Karki, Rajendra , Sundaram, Balamurugan , Sharma, Bhesh Raj , Lee, SangJoon , Malireddi, R. K. Subbarao , Lam Nhat Nguyen , Christgen, Shelbi , Zheng, Min , Wang, Yaqiu , Samir, Parimal , et al

Article Issue Date2021-10 View10
AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence File

Lee, SangJoon , Karki, Rajendra , Wang, Yaqiu , Nguyen, Lam Nhat , Kalathur, Ravi C. , Kanneganti, Thirumala-Devi

Article Issue Date2021-09 View10
Arf6 exacerbates allergic asthma through cell-to-cell transmission of ASC inflammasomes File

Lee, SangJoon , Ishitsuka, Akari , Kuroki, Takahiro , Lin, Yu-Hsien , Shibuya, Akira , Hongu, Tsunaki , Funakoshi, Yuji , Kanaho, Yasunori , Nagata, Kyosuke , Kawaguchi, Atsushi

Article Issue Date2021-08 View12
Influenza Viruses: Innate Immunity and mRNA Vaccines File

Lee, SangJoon , Ryu, Jin-Hyeob

Article Issue Date2021-08 View9
Inflammatory Cell Death, PANoptosis, Mediated by Cytokines in Diverse Cancer Lineages Inhibits Tumor Growth File File

Malireddi, R. K. Subbarao , Karki, Rajendra , Sundaram, Balamurugan , Kancharana, Balabhaskararao , Lee, SangJoon , Samir, Parimal , Kanneganti, Thirumala-Devi

Article Issue Date2021-03 View4
PANoptosis in microbial infection File

Place, David E. , Lee, SangJoon , Kanneganti, Thirumala-Devi

Article Issue Date2021-02 View3
Coronaviruses: Innate Immunity, Inflammasome Activation, Inflammatory Cell Death, and Cytokines File

Lee, SangJoon , Channappanavar, Rudragouda , Kanneganti, Thirumala-Devi

Article Issue Date2020-12 View9
Influenza restriction factor MxA functions as inflammasome sensor in the respiratory epithelium File

Lee, SangJoon , Ishitsuka, Akari , Noguchi, Masayuki , Hirohama, Mikako , Fujiyasu, Yuji , Petric, Philipp P. , Schwemmle, Martin , Staeheli, Peter , Nagata, Kyosuke , Kawaguchi, Atsushi

Article Issue Date2019-10 View9
Stratifin regulates stabilization of receptor tyrosine kinases via interaction with ubiquitin-specific protease 8 in lung adenocarcinoma File

Kim, Yunjung , Shiba-Ishii, Aya , Nakagawa, Tomoki , Iemura, Shun-Ichiro , Natsume, Tohru , Nakano, Noriyuki , Matsuoka, Ryota , Sakashita, Shingo , Lee, SangJoon , Kawaguchi, Atsushi , et al

Article Issue Date2018-10 View9
Influenza A Virus Infection Triggers Pyroptosis and Apoptosis of Respiratory Epithelial Cells through the Type I Interferon Signaling Pathway in a Mutually Exclusive Manner File

Lee, SangJoon , Hirohama, Mikako , Noguchi, Masayuki , Nagata, Kyosuke , Kawaguchi, Atsushi

Article Issue Date2018-07 View9
Inhibition of Influenza Virus Infection by Lentinus edodes Mycelia Extract Through Its Direct Action and Immunopotentiating Activity File File

Kuroki, Takahiro , Lee, Sangjoon , Hirohama, Mikako , Taku, Tomohiro , Kumakura, Michiko , Haruyama, Takahiro , Nagata, Kyosuke , Kawaguchi, Atsushi

Article Issue Date2018-05 View9
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