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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 2416 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 2411 | - |
dc.citation.title | JOURNAL OF IMMUNOLOGY | - |
dc.citation.volume | 207 | - |
dc.contributor.author | Wang, Yaqiu | - |
dc.contributor.author | Karki, Rajendra | - |
dc.contributor.author | Zheng, Min | - |
dc.contributor.author | Kancharana, Balabhaskararao | - |
dc.contributor.author | Lee, SangJoon | - |
dc.contributor.author | Kesavardhana, Sannula | - |
dc.contributor.author | Hansen, Baranda S. | - |
dc.contributor.author | Pruett-Miller, Shondra M. | - |
dc.contributor.author | Kanneganti, Thirumala-Devi | - |
dc.date.accessioned | 2023-12-21T15:07:00Z | - |
dc.date.available | 2023-12-21T15:07:00Z | - |
dc.date.created | 2022-03-08 | - |
dc.date.issued | 2021-11 | - |
dc.description.abstract | Programmed cell death (PCD) is essential for the innate immune response, which serves as the first line of defense against pathogens. Caspases regulate PCD, immune responses, and homeostasis. Caspase-8 specifically plays multifaceted roles in PCD pathways including pyroptosis, apoptosis, and necroptosis. However, because caspase-8-deficient mice are embryonically lethal, little is known about how caspase-8 coordinates different PCD pathways under physiological conditions. Here, we report an anti-inflammatory role of caspase-8 during influenza A virus infection. We generated viable mice carrying an uncleavable version of caspase-8 (Casp8DA/DA). We demonstrated that caspase-8 autoprocessing was responsible for activating caspase-3, thereby suppressing gasdermin D-mediated pyroptosis and inflammatory cytokine release. We also found that apoptotic and pyroptotic pathways were activated at the same time during influenza A virus infection, which enabled the cell-intrinsic anti-inflammatory function of the caspase-8-caspase-3 axis. Our findings provide new insight into the immunological consequences of caspase-8-coordinated PCD crosstalk under physiological conditions. | - |
dc.identifier.bibliographicCitation | JOURNAL OF IMMUNOLOGY, v.207, no.10, pp.2411 - 2416 | - |
dc.identifier.doi | 10.4049/jimmunol.2100757 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.scopusid | 2-s2.0-85121946494 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/57764 | - |
dc.identifier.wosid | 000731636200004 | - |
dc.language | 영어 | - |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | - |
dc.title | Cutting Edge: Caspase-8 Is a Linchpin in Caspase-3 and Gasdermin D Activation to Control Cell Death, Cytokine Release, and Host Defense during Influenza A Virus Infection | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | NECROPTOSIS | - |
dc.subject.keywordPlus | PYROPTOSIS | - |
dc.subject.keywordPlus | CLEAVAGE | - |
dc.subject.keywordPlus | INNATE | - |
dc.subject.keywordPlus | RIPK3 | - |
dc.subject.keywordPlus | FADD | - |
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