CLONING OF CDNA-ENCODING RAT PHOSPHOLIPASE C-BETA-4, A NEW MEMBER OF THE PHOSPHOLIPASE-C
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- CLONING OF CDNA-ENCODING RAT PHOSPHOLIPASE C-BETA-4, A NEW MEMBER OF THE PHOSPHOLIPASE-C
- KIM, MJ; BAHK, YY; MIN, DS; LEE, SJ; RYU, SH; Suh, Pann-Ghill
- Issue Date
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.194, no.2, pp.706 - 712
- Phospholipase C-β4(PLC-β4), a new member of phospholipase C isozyme, was purified from bovine cerebellum. The cDNA encoding rat PLC-β4 has been cloned from a cDNA library prepared from rat brain. The predicted open reading frame encodes a protein of 1,176 amino acids with a calculated molecular weight of 134,552. The deduced amino acid sequence exhibits 39, 36, and 36% identity with the sequences of rat PLC-β1, human PLC-β2, and rat PLC-β3, respectively. The amino acid sequence of PLC-β4, especially, shows higher identity (50%) with norpA PLC sequence from Drosophila melanogaster than those of other PLC-β subtypes, suggesting that the PLC-β4 might be a mammalian PLC equivalent of norpA PLC implicated in photosignal transduction in Drosophila.
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