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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Trp-Lys-Tyr-Met-Val-D-Met stimulates superoxide generation and killing of Staphylococcus aureus via phospholipase D activation in human monocytes

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dc.contributor.author Bae, YS ko
dc.contributor.author Ju, SA ko
dc.contributor.author Kim, JY ko
dc.contributor.author Seo, Jeong Kon ko
dc.contributor.author Baek, SH ko
dc.contributor.author Kwak, JY ko
dc.contributor.author Kim, BS ko
dc.contributor.author Suh, Pann-Ghill ko
dc.contributor.author Ryu, SH ko
dc.date.available 2014-09-04T00:41:35Z -
dc.date.created 2014-09-02 ko
dc.date.issued 1999-02 ko
dc.identifier.citation JOURNAL OF LEUKOCYTE BIOLOGY, v.65, no.2, pp.241 - 248 ko
dc.identifier.issn 0741-5400 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/5703 -
dc.description.abstract Among the phagocytic leukocytes, monocytes have the important role of clearing out parasitic microorganisms. They accomplish this through production of toxic metabolites of oxygen. Trp-Lys-Tyr-Met-Val-D-Met (WKYMVm), a peptide that stimulates phosphoinositide (PI) hydrolysis in human leukocytes, including monocytes, binds to a unique cell surface receptor and stimulates superoxide generation, killing of Staphylococcus aureus, and activation of phospholipase D (PLD) in human monocytes. Preincubation of the cells with a PI-specific phospholipase C (PLC) inhibitor (U-73122), protein kinase C inhibitor (GF109203X), or intracellular Ca 2+ chelator (BAPTA/AM) before the peptide stimulus totally inhibits the peptide-induced PLD activation and superoxide generation. On the other hand, tyrosine kinase inhibitor genistein only partially inhibits the peptide-induced processes. The peptide-induced bacteria killing activity shares regulatory mechanisms for PLD activation with the superoxide generation, which is inhibited in the presence of 1-butanol. We suggest that the peptide stimulates PLD downstream of PLC activation and PLD activation in turn is essential for the peptide- induced immunological functions such as the superoxide generation and killing of bacteria by human monocytes. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher FEDERATION AMER SOC EXP BIOL ko
dc.title Trp-Lys-Tyr-Met-Val-D-Met stimulates superoxide generation and killing of Staphylococcus aureus via phospholipase D activation in human monocytes ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-0033047887 ko
dc.identifier.wosid 000078390200012 ko
dc.type.rims ART ko
dc.description.wostc 43 *
dc.description.scopustc 43 *
dc.date.tcdate 2015-05-06 *
dc.date.scptcdate 2014-09-02 *
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0033047887 ko
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