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DC Field | Value | Language |
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dc.citation.endPage | 248 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 241 | - |
dc.citation.title | JOURNAL OF LEUKOCYTE BIOLOGY | - |
dc.citation.volume | 65 | - |
dc.contributor.author | Bae, YS | - |
dc.contributor.author | Ju, SA | - |
dc.contributor.author | Kim, JY | - |
dc.contributor.author | Seo, Jeong Kon | - |
dc.contributor.author | Baek, SH | - |
dc.contributor.author | Kwak, JY | - |
dc.contributor.author | Kim, BS | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.contributor.author | Ryu, SH | - |
dc.date.accessioned | 2023-12-22T12:12:20Z | - |
dc.date.available | 2023-12-22T12:12:20Z | - |
dc.date.created | 2014-09-02 | - |
dc.date.issued | 1999-02 | - |
dc.description.abstract | Among the phagocytic leukocytes, monocytes have the important role of clearing out parasitic microorganisms. They accomplish this through production of toxic metabolites of oxygen. Trp-Lys-Tyr-Met-Val-D-Met (WKYMVm), a peptide that stimulates phosphoinositide (PI) hydrolysis in human leukocytes, including monocytes, binds to a unique cell surface receptor and stimulates superoxide generation, killing of Staphylococcus aureus, and activation of phospholipase D (PLD) in human monocytes. Preincubation of the cells with a PI-specific phospholipase C (PLC) inhibitor (U-73122), protein kinase C inhibitor (GF109203X), or intracellular Ca 2+ chelator (BAPTA/AM) before the peptide stimulus totally inhibits the peptide-induced PLD activation and superoxide generation. On the other hand, tyrosine kinase inhibitor genistein only partially inhibits the peptide-induced processes. The peptide-induced bacteria killing activity shares regulatory mechanisms for PLD activation with the superoxide generation, which is inhibited in the presence of 1-butanol. We suggest that the peptide stimulates PLD downstream of PLC activation and PLD activation in turn is essential for the peptide- induced immunological functions such as the superoxide generation and killing of bacteria by human monocytes. | - |
dc.identifier.bibliographicCitation | JOURNAL OF LEUKOCYTE BIOLOGY, v.65, no.2, pp.241 - 248 | - |
dc.identifier.issn | 0741-5400 | - |
dc.identifier.scopusid | 2-s2.0-0033047887 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/5703 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0033047887 | - |
dc.identifier.wosid | 000078390200012 | - |
dc.language | 영어 | - |
dc.publisher | FEDERATION AMER SOC EXP BIOL | - |
dc.title | Trp-Lys-Tyr-Met-Val-D-Met stimulates superoxide generation and killing of Staphylococcus aureus via phospholipase D activation in human monocytes | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
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