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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 20 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 16 | - |
dc.citation.title | FEBS LETTERS | - |
dc.citation.volume | 491 | - |
dc.contributor.author | Bae, SS | - |
dc.contributor.author | Choi, Jang Hyun | - |
dc.contributor.author | Oh, YS | - |
dc.contributor.author | Perry, DK | - |
dc.contributor.author | Ryu, SH | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.date.accessioned | 2023-12-22T12:06:06Z | - |
dc.date.available | 2023-12-22T12:06:06Z | - |
dc.date.created | 2014-09-02 | - |
dc.date.issued | 2001-02 | - |
dc.description.abstract | Apoptotic proteases cleave and inactivate survival signaling molecules such as Akt/PKB, phospholipase C (PLC)-gamma1, and Bcl-2. We have found that treatment of A431 cells with tumor necrosis factor-alpha in the presence of cycloheximide resulted in the cleavage of epidermal growth factor receptor (EGFR) as well as the activation of caspase-3. Among various caspases, caspase-1, caspase-3 and caspase-7 were most potent in the cleavage of EGFR in vitro. Proteolytic cleavage of EGFR was inhibited by both YVAD-cmk and DEVD-fmk in vitro. We also investigated the effect of caspase-dependent cleavage of EGFR upon the mediation of signals to downstream signaling molecules such as PLC-gamma1. Cleavage of EGFR by caspase-3 significantly impaired the tyrosine phosphorylation of PLC-gamma1 in vitro. Given these results, we suggest that apoptotic protease specifically cleaves and inactivates EGFR, which plays crucial roles in anti-apoptotic signaling, to abrogate the activation of EGFR-dependent downstream survival signaling molecules | - |
dc.identifier.bibliographicCitation | FEBS LETTERS, v.491, no.1-2, pp.16 - 20 | - |
dc.identifier.doi | 10.1016/S0014-5793(01)02167-6 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.scopusid | 2-s2.0-0035936892 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/5695 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0035936892 | - |
dc.identifier.wosid | 000167248400004 | - |
dc.language | 영어 | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Proteolytic cleavage of epidermal growth factor receptor by caspases | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
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