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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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An Obligatory Role of Mind Bomb-1 in Notch Signaling of Mammalian Development

Cited 50 times inthomson ciCited 42 times inthomson ci
Title
An Obligatory Role of Mind Bomb-1 in Notch Signaling of Mammalian Development
Author
Koo, Bon-KyoungYoon, Mi-JeongYoon, Ki-JunIm, Sun-KyoungKim, Yoon-YoungKim, Cheol-HeeSuh, Pann-GhillJan, Yuh NungKong, Young-Yun
Issue Date
2007-11
Publisher
PUBLIC LIBRARY SCIENCE
Citation
PLOS ONE, v.2, no.11, pp.1 - 12
Abstract
Background. The Notch signaling pathway is an evolutionarily conserved intercellular signaling module essential for cell fate specification that requires endocytosis of Notch ligands. Structurally distinct E3 ubiquitin ligases, Neuralized (Neur) and Mind bomb (Mib), cooperatively regulate the endocytosis of Notch ligands in Drosophila. However, the respective roles of the mammalian E3 ubiquitin ligases, Neur1, Neur2, Mib1, and Mib2, in mammalian development are poorly understood. Methodology/Principal Findings. Through extensive use of mammalian genetics, here we show that Neur1 and Neur2 double mutants and Mib2-1- mice were viable and grossly normal. In contrast, conditional inactivation of MW in various tissues revealed the representative Notch phenotypes: defects of arterial specification as deltalike4 mutants, abnormal cerebellum and skin development as jagged1 conditional mutants, and syndactylism as jagged2 mutants. Conclusions/Significance. Our data provide the first evidence that Mib1 is essential for Jagged as well as Deltalike ligand-mediated Notch signaling in mammalian development, while Neur1, Neur2, and Mib2 are dispensable.
URI
https://scholarworks.unist.ac.kr/handle/201301/5610
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=43249100317
DOI
10.1371/journal.pone.0001221
ISSN
1932-6203
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BIO_Journal Papers
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