There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 1176 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1169 | - |
dc.citation.title | CHEMICAL SCIENCE | - |
dc.citation.volume | 13 | - |
dc.contributor.author | Nguyen, Nguyen Hoang | - |
dc.contributor.author | Oh, Soo Min | - |
dc.contributor.author | Park, Cheol-Min | - |
dc.contributor.author | Shin, Seunghoon | - |
dc.date.accessioned | 2023-12-21T14:43:17Z | - |
dc.date.available | 2023-12-21T14:43:17Z | - |
dc.date.created | 2022-01-03 | - |
dc.date.issued | 2022-01 | - |
dc.description.abstract | Control over chemo- and regioselectivity is a critical issue in the heterobiaryl synthesis via C-H oxidative coupling. To address this challenge, a strategy to invert the normal polarity of indoles in the heterobiaryl coupling was developed. With N-carboxyindoles as umpoled indoles, an exclusively ortho-selective coupling with phenols has been realized, employing Brønsted acid- or Cu(I)-catalyst (as low as 0.01 mol%). A range of phenols and N-carboxyindoles coupled with exceptional efficiency and selectivity at ambient temperature and the substrates bearing redox-active aryl halides (-Br and -I) smoothly coupled in an orthogonal manner. Notably, preliminary examples of atropselective heterobiaryl coupling have been demonstrated, based on a chiral disulfonimide or a Cu(I)/chiral bisphosphine catalytic system. The reaction was proposed to occur through SN2’ substitution or a Cu(I)-Cu(III) cycle, with Brønsted acid or Cu(I) catalysts, respectively. | - |
dc.identifier.bibliographicCitation | CHEMICAL SCIENCE, v.13, no.4, pp.1169 - 1176 | - |
dc.identifier.doi | 10.1039/d1sc06157g | - |
dc.identifier.issn | 2041-6520 | - |
dc.identifier.scopusid | 2-s2.0-85123686974 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/55890 | - |
dc.identifier.wosid | 000741968700001 | - |
dc.language | 영어 | - |
dc.publisher | Royal Society of Chemistry | - |
dc.title | Ortho-selective C-H arylation of phenols with N-carboxyindoles under Bronsted acid- or Cu(i)-catalysis | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.