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Cho, Yoon-Kyoung
Integrated Nano-Biotech Lab (INBL)
Research Interests
  • Microfluidics, Lab-on-a-chip, personalized biomedical diagnostics, nanobioengineering

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Clinical significance of circulating tumor cells after chemotherapy in unresectable pancreatic ductal adenocarcinoma

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Title
Clinical significance of circulating tumor cells after chemotherapy in unresectable pancreatic ductal adenocarcinoma
Author
Kim, HyeminHeo, Chan MiOh, JinmyeongChung, Hwe HoonLee, Eun MiPark, JuheeLee, Se-HoonLee, Kwang HyuckLee, Kyu TaekLee, Jong KyunCho, Yoon-KyoungPark, Joo Kyung
Issue Date
2022-02
Publisher
Neoplasia Press
Citation
TRANSLATIONAL ONCOLOGY, v.16, pp.101321
Abstract
Circulating tumor cells (CTCs) have emerged as liquid biopsy biomarker providing non-invasive assessment of cancer progression and biology. We investigated whether longitudinal analysis of CTCs could monitor disease progression, response to chemotherapy, and survival in patients with unresectable pancreatic ductal adenocarcinoma (PDAC). A total of 52 patients with PDAC were prospectively enrolled in this study. Peripheral blood samples were serially collected at the time of diagnosis and after chemotherapy with clinical assessments. CTCs were isolated through a centrifugal microfluidic disc, enumerated with immunostaining against Epithelial cell adhesion molecule (EpCAM), Cytokeratin (CK), Plectin-1 and CD45, and identified by an automated imaging system. One or more CTCs were detected in 84.62% patients with unresectable PDAC at the time of diagnosis. CTC numbers were not statistically different across tumor sizes, location and metastatic sites. The absolute number of CTCs after chemotherapy was inversely related to overall survival (OS), and the decreased number of CTCs after chemotherapy was significantly associated with longer OS in patients with PDAC. Identifying CTCs and monitoring CTC changes after chemotherapy could be a useful prognostic marker for survival in patients with unresectable PDACs.
URI
https://scholarworks.unist.ac.kr/handle/201301/55864
DOI
10.1016/j.tranon.2021.101321
ISSN
1936-5233
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BME_Journal Papers
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