Full metadata record
DC Field | Value | Language |
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dc.citation.endPage | 11102 | - |
dc.citation.number | 19 | - |
dc.citation.startPage | 11083 | - |
dc.citation.title | NUCLEIC ACIDS RESEARCH | - |
dc.citation.volume | 49 | - |
dc.contributor.author | Kim, Jae Jin | - |
dc.contributor.author | Lee, Seo Yun | - |
dc.contributor.author | Hwang, Yiseul | - |
dc.contributor.author | Kim, Soyeon | - |
dc.contributor.author | Chung, Jee Min | - |
dc.contributor.author | Park, Sangwook | - |
dc.contributor.author | Yoon, Junghyun | - |
dc.contributor.author | Yun, Hansol | - |
dc.contributor.author | Ji, Jae-Hoon | - |
dc.contributor.author | Chae, Sunyoung | - |
dc.contributor.author | Cho, Hyeseong | - |
dc.contributor.author | Kim, Chan Gil | - |
dc.contributor.author | Dawson, Ted M. | - |
dc.contributor.author | Kim, Hongtae | - |
dc.contributor.author | Dawson, Valina L. | - |
dc.contributor.author | Kang, Ho Chul | - |
dc.date.accessioned | 2023-12-21T15:07:09Z | - |
dc.date.available | 2023-12-21T15:07:09Z | - |
dc.date.created | 2021-12-30 | - |
dc.date.issued | 2021-11 | - |
dc.description.abstract | Mutual crosstalk among poly(ADP-ribose) (PAR), activated PAR polymerase 1 (PARP1) metabolites, and DNA repair machinery has emerged as a key regulatory mechanism of the DNA damage response (DDR). However, there is no conclusive evidence of how PAR precisely controls DDR. Herein, six deubiquitinating enzymes (DUBs) associated with PAR-coupled DDR were identified, and the role of USP39, an inactive DUB involved in spliceosome assembly, was characterized. USP39 rapidly localizes to DNA lesions in a PAR-dependent manner, where it regulates non-homologous end-joining (NHEJ) via a tripartite RG motif located in the N-terminus comprising 46 amino acids (N46). Furthermore, USP39 acts as a molecular trigger for liquid demixing in a PAR-coupled N46-dependent manner, thereby directly interacting with the XRCC4/LIG4 complex during NHEJ. In parallel, the USP39-associated spliceosome complex controls homologous recombination repair in a PAR-independent manner. These findings provide mechanistic insights into how PAR chains precisely control DNA repair processes in the DDR. | - |
dc.identifier.bibliographicCitation | NUCLEIC ACIDS RESEARCH, v.49, no.19, pp.11083 - 11102 | - |
dc.identifier.doi | 10.1093/nar/gkab892 | - |
dc.identifier.issn | 0305-1048 | - |
dc.identifier.scopusid | 2-s2.0-85120687786 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/55668 | - |
dc.identifier.url | https://academic.oup.com/nar/article/49/19/11083/6382377 | - |
dc.identifier.wosid | 000720750900024 | - |
dc.language | 영어 | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.title | USP39 promotes non-homologous end-joining repair by poly(ADP-ribose)-induced liquid demixing | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | DNA-DAMAGE RESPONSE | - |
dc.subject.keywordPlus | PHASE-SEPARATION | - |
dc.subject.keywordPlus | DEUBIQUITYLATING ENZYMES | - |
dc.subject.keywordPlus | HOMOLOGOUS RECOMBINATION | - |
dc.subject.keywordPlus | DEPENDENT RECRUITMENT | - |
dc.subject.keywordPlus | ADP-RIBOSYLATION | - |
dc.subject.keywordPlus | BREAK REPAIR | - |
dc.subject.keywordPlus | BRCA1 | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | UBIQUITIN | - |
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