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Grzybowski, Bartosz A.
School of Natural Science
Research Interests
  • Nano science
  • Nanomaterials
  • Programmable Reactions
  • Chemical Networks
  • Cellular Dynamics

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On-Nanoparticle Gating Units Render an Ordinary Catalyst Substrate- and Site-Selective

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Title
On-Nanoparticle Gating Units Render an Ordinary Catalyst Substrate- and Site-Selective
Author
Kim, MinjuDygas, MiroslawSobolev, Yaroslav, IBeker, WiktorZhuang, QiangKlucznik, TomaszAhumada, GuillermoAhumada, Juan CarlosGrzybowski, Bartosz A.
Issue Date
2021-02
Publisher
AMER CHEMICAL SOC
Citation
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.143, no.4, pp.1807 - 1815
Abstract
When an organometallic catalyst is tethered onto a nanoparticle and is embedded in a monolayer of longer ligands terminated in "gating" end-groups, these groups can control the access and orientation of the incoming substrates. In this way, a nonspecific catalyst can become enzyme-like: it can select only certain substrates from substrate mixtures and, quite remarkably, can also preorganize these substrates such that only some of their otherwise equivalent sites react. For a simple, copper-based click reaction catalyst and for gating ligands terminated in charged groups, both substrate- and site-selectivities are on the order of 100, which is all the more notable given the relative simplicity of the on-particle monolayers compared to the intricacy of enzymes' active sites. The strategy of self-assembling macromolecular, on-nanoparticle environments to enhance selectivities of "ordinary" catalysts presented here is extendable to other types of catalysts and gating based on electrostatics, hydrophobicity, and chirality, or the combinations of these effects. Rational design of such systems should be guided by theoretical models we also describe.
URI
https://scholarworks.unist.ac.kr/handle/201301/55401
URL
https://pubs.acs.org/doi/10.1021/jacs.0c09408
DOI
10.1021/jacs.0c09408
ISSN
0002-7863
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CHM_Journal Papers
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