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Grzybowski, Bartosz A.
School of Natural Science
Research Interests
  • Nano science
  • Nanomaterials
  • Programmable Reactions
  • Chemical Networks
  • Cellular Dynamics

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Is Organic Chemistry Really Growing Exponentially?

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Title
Is Organic Chemistry Really Growing Exponentially?
Author
Szymkuc, SaraBadowski, TomaszGrzybowski, Bartosz A.
Issue Date
2021-12
Publisher
WILEY-V C H VERLAG GMBH
Citation
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.60, no.50, pp.26226 - 26232
Abstract
In terms of molecules and specific reaction examples, organic chemistry features an impressive, exponential growth. However, new reaction classes/types that fuel this growth are being discovered at a much slower and only linear (or even sublinear) rate. The proportion of newly discovered reaction types to all reactions being performed keeps decreasing, suggesting that synthetic chemistry becomes more reliant on reusing the well-known methods. The newly discovered chemistries are more complex than decades ago and allow for the rapid construction of complex scaffolds in fewer numbers of steps. We study these and other trends in the function of time, reaction-type popularity and complexity based on the algorithm that extracts generalized reaction class templates. These analyses are useful in the context of computer-assisted synthesis, machine learning (to estimate the numbers of models with sufficient reaction statistics), and identifying erroneous entries in reaction databases.
URI
https://scholarworks.unist.ac.kr/handle/201301/55328
DOI
10.1002/anie.202111540
ISSN
1433-7851
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CHM_Journal Papers
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