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Park, Tae Joo
Developmental Morphogenesis Lab
Research Interests
  • Morphogenesis, chondrogenesis, ciliogenesis


Physiological Functions of Thiol Peroxidases (Gpx1 and Prdx2) during Xenopus laevis Embryonic Development

DC Field Value Language Lee, Hongchan ko Lee, Na Young ko Kim, Youni ko Choi, Hong-Seok ko Ismail, Tayaba ko Ryu, Hong-Yeoul ko Cho, Dong-Hyung ko Ryoo, Zae Young ko Lee, Dong-Seok ko Kwon, Taeg Kyu ko Park, Tae Joo ko Kwon, Taejoon ko Lee, Hyun-Shik ko 2021-11-18T08:42:13Z - 2021-11-15 ko 2021-10 ko
dc.identifier.citation ANTIOXIDANTS, v.10, no.10, pp.1636 ko
dc.identifier.issn 2076-3921 ko
dc.identifier.uri -
dc.description.abstract Glutathione peroxidase 1 (Gpx1) and peroxiredoxin 2 (Prdx2) belong to the thiol peroxidase family of antioxidants, and have been studied for their antioxidant functions and roles in cancers. However, the physiological significance of Gpx1 and Prdx2 during vertebrate embryogenesis are lacking. Currently, we investigated the functional roles of Gpx1 and Prdx2 during vertebrate embryogenesis using Xenopus laevis as a vertebrate model. Our investigations revealed the zygotic nature of gpx1 having its localization in the eye region of developing embryos, whereas prdx2 exhibited a maternal nature and were localized in embryonic ventral blood islands. Furthermore, the gpx1-morphants exhibited malformed eyes with incompletely detached lenses. However, the depletion of prdx2 has not established its involvement with embryogenesis. A molecular analysis of gpx1-depleted embryos revealed the perturbed expression of a cryba1-lens-specific marker and also exhibited reactive oxygen species (ROS) accumulation in the eye regions of gpx1-morphants. Additionally, transcriptomics analysis of gpx1-knockout embryos demonstrated the involvement of Wnt, cadherin, and integrin signaling pathways in the development of malformed eyes. Conclusively, our findings indicate the association of gpx1 with a complex network of embryonic developmental pathways and ROS responses, but detailed investigation is a prerequisite in order to pinpoint the mechanistic details of these interactions.</p> ko
dc.language 영어 ko
dc.publisher MDPI AG ko
dc.title Physiological Functions of Thiol Peroxidases (Gpx1 and Prdx2) during Xenopus laevis Embryonic Development ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-85117086132 ko
dc.identifier.wosid 000715476500001 ko
dc.type.rims ART ko
dc.identifier.doi 10.3390/antiox10101636 ko
dc.identifier.url ko
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