Enhanced biaxial stretchability of highly impermeable SiO2 encapsulation thin film with wrinkle struc-tures is demonstrated. Submicron-thick SiO2 films are grown on single-crystalline Si wafers to endure local strain on wrinkled film, and their high elastic deformation limit stabilizes wrinkle structure. SiO2 films are transferred onto prestrained elastomer, and two types of wrinkle structures are formed by re-moval of the prestrain: aligned wrinkles by uniaxial prestrain and random wrinkles by equibiaxial pre-strain. The stretchability of the large area film is correlated with the unwrinkling of individual wrinkles, and a mechanics model is suggested to predict stretchability with parameters of wrinkle morphology as well as elastic properties of the encapsulation film and the elastomer substrate.