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Kwak, Sang Kyu
Kyu’s MolSim Lab @ UNIST
Research Interests
  • Molecular modeling and simulation, statistical thermodynamics, molecular physics

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Intramitochondrial Disulfide Polymerization Controls Cancer Cell Fate

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Title
Intramitochondrial Disulfide Polymerization Controls Cancer Cell Fate
Author
Kim, SangpilJana, BatakrishnaGo, Eun MinLee, Ji EunJin, SeongeonAn, Eun-KoungHwang, JuyoungSim, YoujungSon, SeheeKim, DohyunKim, ChaekyuJin, Jun-OKwak, Sang KyuRyu, Ja-Hyoung
Issue Date
2021-09
Publisher
AMER CHEMICAL SOC
Citation
ACS NANO, v.15, no.9, pp.14492 - 14508
Abstract
Recent advances in supramolecular chemistry research have led to the development of artificial chemical systems that can form self-assembled structures that imitate proteins involved in the regulation of cellular function. However, intracellular polymerization systems that operate inside living cells have been seldom reported. In this study, we developed an intramitochondrial polymerization-induced self-assembly system for regulating the cellular fate of cancer cells. It showed that polymeric disulfide formation inside cells occurred due to the high reactive oxygen species (ROS) concentration of cancer mitochondria. This polymerization barely occurs elsewhere in the cell owing to the reductive intracellular environment. The polymerization of the thiol-containing monomers further increases the ROS level inside the mitochondria, thereby autocatalyzing the polymerization process and creating fibrous polymeric structures. This process induces dysfunction of the mitochondria, which in turn activates cell necroptosis. Thus, this in situ polymerization system shows great potential for cancer treatment, including that of drug-resistant cancers.
URI
https://scholarworks.unist.ac.kr/handle/201301/53994
URL
https://pubs.acs.org/doi/10.1021/acsnano.1c04015
DOI
10.1021/acsnano.1c04015
ISSN
1936-0851
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CHM_Journal Papers
ECHE_Journal Papers
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