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- Park, Sung Ho
- Laboratory of Molecular Immunology
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An Impaired Inflammatory and Innate Immune Response in COVID-19
- Author(s)
- Park, Sung Ho
- Issued Date
- 2021-06
- Citation
- MOLECULES AND CELLS, v.44, no.6, pp.384 - 391
- Abstract
- The recent appearance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people around the world and caused a global pandemic of coronavirus disease 2019 (COVID-19). It has been suggested that uncontrolled, exaggerated inflammation contributes to the adverse outcomes of COVID-19. In this review, we summarize our current understanding of the innate immune response elicited by SARS-CoV-2 infection and the hyperinflammation that contributes to disease severity and death. We also discuss the immunological determinants behind COVID-19 severity and propose a rationale for the underlying mechanisms.
- Publisher
- KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
- ISSN
- 1016-8478
- Keyword (Author)
- COVID-19, cytokine storm, immunoparalysis, inflammatory cytokines, innate immune response
- Keyword
- I INTERFERONS, MILD, CELL, INFECTION
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