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DC Field | Value | Language |
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dc.citation.startPage | 103132 | - |
dc.citation.title | DNA REPAIR | - |
dc.citation.volume | 104 | - |
dc.contributor.author | Ye, Byeong Jin | - |
dc.contributor.author | Kang, Hyun Je | - |
dc.contributor.author | Lee-Kwon, Whaseon | - |
dc.contributor.author | Kwon, Hyug Moo | - |
dc.contributor.author | Choi, Soo Youn | - |
dc.date.accessioned | 2023-12-21T15:36:57Z | - |
dc.date.available | 2023-12-21T15:36:57Z | - |
dc.date.created | 2021-08-18 | - |
dc.date.issued | 2021-08 | - |
dc.description.abstract | Lack of coordination between the DNA replication and transcription machineries can increase the frequency of transcription-replication conflicts, leading ultimately to DNA damage and genomic instability. A major source of these conflicts is the formation of R-loops, which consist of a transcriptionally generated RNA-DNA hybrid and the displaced single-stranded DNA. R-loops play important physiological roles and have been implicated in human diseases. Although these structures have been extensively studied, many aspects of R-loop biology and Rloop-mediated genome instability remain unclear. We found that in cancer cells, tonicity-responsive enhancerbinding protein (TonEBP, also called NFAT5) interacted with PARP1 and localized to R-loops in response to DNAdamaging agent camptothecin (CPT), which is associated with R-loop formation. PARP1-mediated PARylation was required for recruitment of TonEBP to the sites of R-loop-associated DNA damage. Loss of TonEBP increased levels of R-loop accumulation and DNA damage, and promoted cell death in response to CPT. These findings suggest that TonEBP mediates resistance to CPT-induced cell death by preventing R-loop accumulation in cancer cells. | - |
dc.identifier.bibliographicCitation | DNA REPAIR, v.104, pp.103132 | - |
dc.identifier.doi | 10.1016/j.dnarep.2021.103132 | - |
dc.identifier.issn | 1568-7864 | - |
dc.identifier.scopusid | 2-s2.0-85106488900 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/53489 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1568786421000884?via%3Dihub | - |
dc.identifier.wosid | 000680521300008 | - |
dc.language | 영어 | - |
dc.publisher | ELSEVIER | - |
dc.title | PARP1-mediated PARylation of TonEBP prevents R-loop-associated DNA damage | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity; Toxicology | - |
dc.relation.journalResearchArea | Genetics & Heredity; Toxicology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | NFAT5 | - |
dc.subject.keywordAuthor | PARylation | - |
dc.subject.keywordAuthor | Camptothecin | - |
dc.subject.keywordAuthor | DNA damage response | - |
dc.subject.keywordAuthor | DNA repair | - |
dc.subject.keywordAuthor | Genome instability | - |
dc.subject.keywordAuthor | Cancer cell | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | GENOME | - |
dc.subject.keywordPlus | REPLICATION | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | THREATS | - |
dc.subject.keywordPlus | REPAIR | - |
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